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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Development of anti-citrullinated protein antibody and rheumatoid factor isotypes prior to the onset of rheumatoid arthritis

Figure 1

Anti-citrullinated protein antibody (ACPA) and rheumatoid factor (RF) levels rise prior to onset of rheumatoid arthritis. For better comparison, antibody levels were normalized to the percentage of the last available sample. The median ACPA levels rose significantly from 11 to 23, 32 to 48, and 24 to 358 AU/mL for IgA, IgM, and IgG, respectively (P <0.001 for all values, Wilcoxon signed-rank test). The median RF levels rose significantly from 15 to 52 IU/mL, 5 to 43 IU/mL, and 10 to 30 μg/mL for IgA, IgM, and IgG, respectively (P <0.001 for all values, Wilcoxon signed-rank test). ACPA, anti-citrullinated protein antibody; T1, first available sample; T2, second available sample; T3, last available sample.

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