Locus | SNP | MAF†| β | SE | P-value |
|---|
GC
| rs2282679 | 0.259 (A/C) | -0.13 | 0.033 | 8.1 × 10-5 |
DHCR7/NADSYN1
| rs3829251 | 0.375 (G/A) | -0.0031 | 0.032 | 0.92 |
rs12785878 | 0.328 (G/T) | 0.0057 | 0.032 | 0.86 |
rs1790349 | 0.361 (A/G) | -0.016 | 0.032 | 0.63 |
CYP2R1
| rs10741657 | 0.387 (G/A) | 0.035 | 0.034 | 0.30 |
- All analyses were adjusted for independent non-genetic risk factors: gender, age, Japanese version of the Health Assessment Questionnaire disability score, total protein level, total cholesterol level, alkaline phosphate level, and non-steroidal anti-inflammatory drugs use[12]. †Alleles are listed as major allele/minor allele. SNP, single nucleotide polymorphism; MAF, minor allele frequency; SE, standard error; GC, group-specific component; DHCR7/NADSYN1, 7-dehydrocholesterol reductase/nicotinamide-adenine dinucleotide synthetase 1; CYP2R1, cytochrome P450, family 2, subfamily R, polypeptide 1.
