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Table 1 Characteristics of individuals without rheumatoid arthritis (RA) or osteoarthritis (OA) at baseline

From: Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trøndelag health study (HUNT)

  All participants without RA/OA Later developed RA Did not develop RA P-value Later developed OA Did not develop OA P-value
n 33,567 786 32,781   3,586 29,981  
Age 1 (years) 46 (13) 51 (13) 46 (13) ** 52 (10) 45 (13) **
Sex (female) 18,207 (54.2%) 488 (62.1%) 17719 (54.1%) ** 2,406 (67.1%) 15,801(52.7%) **
Smoking     **    **
Current 8,901 (26.5%) 256 (32.6%) 8,645 (26.4%)   1,015 (28.3%) 7,886 (26.3%)  
Former smoker 7,908 (23.6%) 212 (27.0%) 7,696 (23.5%)   945 (26.4%) 6,963 (23.2%)  
Never smoker 15,017 (44.7%) 281 (35.6%) 14,736 (45.0%)   1,425 (39.7%) 13,592 (45.3%)  
Hypertension 12,186 (36.3%) 339 (43.1%) 11,847 (36.1%) ** 1,547 (43.1%) 10,639 (35.5%) **
Diabetes 454 (1.4%) 19 (2.4%) 435 (1.3%) * 61 (1.7%) 393 (1.3%)  
Previous CV disease 1,060 (3.2%) 52 (6.6%) 1,008 (3.1%) ** 158 (4.4%) 902 (3.0%) **
Angina 673 (2.0%) 35 (4.5%) 638 (1.9%) ** 107 (3.0%) 566 (1.9%) **
MI 441 (1.3%) 16 (2.0%) 425(1.3%)   49 (1.4%) 392 (1.3%)  
Stroke 223 (0.7%) 9 (1.1%) 214 (0.7%)   32 (0.9%) 191 (0.6%)  
Family risk of CV disease 15,692 (46.7%) 414 (52.7%) 15,278 (46.6%) ** 2,017 (56.2%) 13,675 (45.6%) **
Framingham risk score 2 9 (4 to 13) 11 (7 to 16) 8 (4 to 13)   11 (7 to 15) 8 (3 to 13)  
Weight 1 (kg) 76 (14) 77 (14) 76 (14)   77 (13) 76 (14)  
BMI 2 (kg/m 2 ) 25.6 (23.5 to 28.1) 26.3 (24.3 to 29.0) 25.6 (23.4 to 28.1) ** 26.4 (24.2 to 29.0) 25.4 (23.3 to 27.8) **
Waist circumference 1 (cm) 85 (11) 86 (11) 85 (11) * 86 (11) 85 (11) **
Hip circumference 1 (cm) 102 (8) 103 (8) 102 (8) ** 103 (8) 101 (6) **
Waist/hip ratio 1 0.84 (0.08) 0.84 (0.08) 0.84 (0.08)   0.83 (0.07) 0.84 (0.08) **
Systolic blood pressure 2 (mmHg) 131 (120 to 144) 133 (122 to 146) 131 (120 to 144) * 133 (122 to 147) 131 (120 to 143) **
Diastolic blood pressure 1 (mmHg) 79 (11) 80 (11) 79 (11) * 81 (11) 79 (11) **
Serum cholesterol 1 (mmol/L) 5.8 (1.2) 6.0 (1.2) 5.8 (1.2) ** 6.1 (1.2) 5.8 (1.2) **
HDL cholesterol 1 (mmol/L) 1.40 (0.39) 1.37 (0.39) 1.40 (0.39)   1.44 (0.40) 1.39 (0.38) **
Serum triglycerides 2 (mmol/L) 1.40 (0.98 to 2.07) 1.51 (1.10 to 2.24) 1.40 (0.97 to 2.06) ** 1.46 (1.02 to 2.12) 1.37 (0.95 to 2.04) **
  1. 1Values are mean (standard deviation) or numbers (%), or 2median (interquartile range). Non-respondents were excluded. BMI, body mass index; CVD, cardiovascular disease; HDL, high density lipoprotein; MI, myocardial infarction; OA, osteoarthritis; RA, rheumatoid arthritis. *P-value <0.05, **P-value <0.001, comparing individuals who developed RA and did not develop RA, or comparing individuals who developed OA and did not develop OA. All blood samples were non-fasting.