All participants without RA/OA | Later developed RA | Did not develop RA | P-value | Later developed OA | Did not develop OA | P-value | |
---|---|---|---|---|---|---|---|
n | 33,567 | 786 | 32,781 | 3,586 | 29,981 | ||
Age 1 (years) | 46 (13) | 51 (13) | 46 (13) | ** | 52 (10) | 45 (13) | ** |
Sex (female) | 18,207 (54.2%) | 488 (62.1%) | 17719 (54.1%) | ** | 2,406 (67.1%) | 15,801(52.7%) | ** |
Smoking | ** | ** | |||||
Current | 8,901 (26.5%) | 256 (32.6%) | 8,645 (26.4%) | 1,015 (28.3%) | 7,886 (26.3%) | ||
Former smoker | 7,908 (23.6%) | 212 (27.0%) | 7,696 (23.5%) | 945 (26.4%) | 6,963 (23.2%) | ||
Never smoker | 15,017 (44.7%) | 281 (35.6%) | 14,736 (45.0%) | 1,425 (39.7%) | 13,592 (45.3%) | ||
Hypertension | 12,186 (36.3%) | 339 (43.1%) | 11,847 (36.1%) | ** | 1,547 (43.1%) | 10,639 (35.5%) | ** |
Diabetes | 454 (1.4%) | 19 (2.4%) | 435 (1.3%) | * | 61 (1.7%) | 393 (1.3%) | |
Previous CV disease | 1,060 (3.2%) | 52 (6.6%) | 1,008 (3.1%) | ** | 158 (4.4%) | 902 (3.0%) | ** |
Angina | 673 (2.0%) | 35 (4.5%) | 638 (1.9%) | ** | 107 (3.0%) | 566 (1.9%) | ** |
MI | 441 (1.3%) | 16 (2.0%) | 425(1.3%) | 49 (1.4%) | 392 (1.3%) | ||
Stroke | 223 (0.7%) | 9 (1.1%) | 214 (0.7%) | 32 (0.9%) | 191 (0.6%) | ||
Family risk of CV disease | 15,692 (46.7%) | 414 (52.7%) | 15,278 (46.6%) | ** | 2,017 (56.2%) | 13,675 (45.6%) | ** |
Framingham risk score 2 | 9 (4 to 13) | 11 (7 to 16) | 8 (4 to 13) | 11 (7 to 15) | 8 (3 to 13) | ||
Weight 1 (kg) | 76 (14) | 77 (14) | 76 (14) | 77 (13) | 76 (14) | ||
BMI 2 (kg/m 2 ) | 25.6 (23.5 to 28.1) | 26.3 (24.3 to 29.0) | 25.6 (23.4 to 28.1) | ** | 26.4 (24.2 to 29.0) | 25.4 (23.3 to 27.8) | ** |
Waist circumference 1 (cm) | 85 (11) | 86 (11) | 85 (11) | * | 86 (11) | 85 (11) | ** |
Hip circumference 1 (cm) | 102 (8) | 103 (8) | 102 (8) | ** | 103 (8) | 101 (6) | ** |
Waist/hip ratio 1 | 0.84 (0.08) | 0.84 (0.08) | 0.84 (0.08) | 0.83 (0.07) | 0.84 (0.08) | ** | |
Systolic blood pressure 2 (mmHg) | 131 (120 to 144) | 133 (122 to 146) | 131 (120 to 144) | * | 133 (122 to 147) | 131 (120 to 143) | ** |
Diastolic blood pressure 1 (mmHg) | 79 (11) | 80 (11) | 79 (11) | * | 81 (11) | 79 (11) | ** |
Serum cholesterol 1 (mmol/L) | 5.8 (1.2) | 6.0 (1.2) | 5.8 (1.2) | ** | 6.1 (1.2) | 5.8 (1.2) | ** |
HDL cholesterol 1 (mmol/L) | 1.40 (0.39) | 1.37 (0.39) | 1.40 (0.39) | 1.44 (0.40) | 1.39 (0.38) | ** | |
Serum triglycerides 2 (mmol/L) | 1.40 (0.98 to 2.07) | 1.51 (1.10 to 2.24) | 1.40 (0.97 to 2.06) | ** | 1.46 (1.02 to 2.12) | 1.37 (0.95 to 2.04) | ** |