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Table 2 Effects of risk factors on incident RA and osteoarthritis, by multivariate logistic regression
| Odds ratio | 95% confidence interval | P-value | |
|---|---|---|---|
| I - Main model – Rheumatoid arthritis (n = 739 patients and 30,829 controls)1 | |||
| Female gender | 1.50 | 1.29 to 1.75 | <0.01 |
| Age2 | 1.03 | 1.02 to 1.04 | <0.001 |
| Current smoker | 1.64 | 1.38 to 1.96 | <0.001 |
| Former smoker | 1.32 | 1.10 to 1.59 | <0.01 |
| Hypertension | 0.97 | 0.82 to 1.15 | 0.76 |
| Diabetes | 1.34 | 0.83 to 2.18 | 0.23 |
| Body mass index2 | 1.04 | 1.02 to 1.06 | <0.001 |
| Previous CV disease | 1.52 | 1.11 to 2.07 | <0.01 |
| II - Alternative models (sensitivity analyses) - Rheumatoid arthritis | |||
| A – After exclusion of patients with self-reported psoriasis (n = 573 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 1.70 | 1.23 to 2.36 | 0.001 |
| B – Including patients with hospital diagnosis of RA (n = 201 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 1.90 | 1.10 to 3.27 | 0.02 |
| C – Including patients with hospital diagnosis of RA after 1999 (n = 178 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 2.26 | 1.26 to 3.99 | |
| D – Including patients with hospital diagnosis of RA after 2001 (n = 138 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 2.51 | 1.33 to 4.73 | <0.01 |
| E – Including patients carrying the Shared Epitope (n = 313 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 1.76 | 1.13 to 2.74 | 0.01 |
| F – Including patients carrying the Shared Epitope and excluding patients with self-reported psoriasis (n = 257 patients and 30,829 controls)1 | |||
| Previous CV disease3 | 1.96 | 1.24 to 3.10 | <0.01 |
| III - Model for osteoarthritis (n = 3,364 patients and 24,631 controls)1 | |||
| Female gender | 2.36 | 2.15 to 2.56 | <0.001 |
| Age2 | 1.05 | 1.05 to 1.06 | <0.001 |
| Current smoker | 1.42 | 1.30 to 1.56 | <0.001 |
| Former smoker | 1.23 | 1.12 to 1.35 | <0.001 |
| Diabetes | 0.90 | 0.66 to 1.22 | 0.49 |
| Body mass index2 | 1.06 | 1.05 to 1.07 | <0.001 |
| Previous CV disease | 1.04 | 0.86 to 1.27 | 0.66 |
