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Table 2 Effects of risk factors on incident RA and osteoarthritis, by multivariate logistic regression

From: Cardiovascular disease is increased prior to onset of rheumatoid arthritis but not osteoarthritis: the population-based Nord-Trøndelag health study (HUNT)

  Odds ratio 95% confidence interval P-value
I - Main model – Rheumatoid arthritis (n = 739 patients and 30,829 controls)1
  Female gender 1.50 1.29 to 1.75 <0.01
  Age2 1.03 1.02 to 1.04 <0.001
  Current smoker 1.64 1.38 to 1.96 <0.001
  Former smoker 1.32 1.10 to 1.59 <0.01
  Hypertension 0.97 0.82 to 1.15 0.76
  Diabetes 1.34 0.83 to 2.18 0.23
  Body mass index2 1.04 1.02 to 1.06 <0.001
  Previous CV disease 1.52 1.11 to 2.07 <0.01
II - Alternative models (sensitivity analyses) - Rheumatoid arthritis
  A – After exclusion of patients with self-reported psoriasis (n = 573 patients and 30,829 controls)1
  Previous CV disease3 1.70 1.23 to 2.36 0.001
  B – Including patients with hospital diagnosis of RA (n = 201 patients and 30,829 controls)1
  Previous CV disease3 1.90 1.10 to 3.27 0.02
  C – Including patients with hospital diagnosis of RA after 1999 (n = 178 patients and 30,829 controls)1
  Previous CV disease3   2.26 1.26 to 3.99
  D – Including patients with hospital diagnosis of RA after 2001 (n = 138 patients and 30,829 controls)1
  Previous CV disease3 2.51 1.33 to 4.73 <0.01
  E – Including patients carrying the Shared Epitope (n = 313 patients and 30,829 controls)1
  Previous CV disease3 1.76 1.13 to 2.74 0.01
  F – Including patients carrying the Shared Epitope and excluding patients with self-reported psoriasis (n = 257 patients and 30,829 controls)1
  Previous CV disease3 1.96 1.24 to 3.10 <0.01
III - Model for osteoarthritis (n = 3,364 patients and 24,631 controls)1
  Female gender 2.36 2.15 to 2.56 <0.001
  Age2 1.05 1.05 to 1.06 <0.001
  Current smoker 1.42 1.30 to 1.56 <0.001
  Former smoker 1.23 1.12 to 1.35 <0.001
  Diabetes 0.90 0.66 to 1.22 0.49
  Body mass index2 1.06 1.05 to 1.07 <0.001
  Previous CV disease 1.04 0.86 to 1.27 0.66
  1. 1Cases with complete data.
  2. 2Continuous variable, Odds ratio per one unit change.
  3. 3Multivariate model including the same variables as the main model for RA. CV, cardiovascular; RA, rheumatoid arthritis.
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