Table 2 Effects of risk factors on incident RA and osteoarthritis, by multivariate logistic regression

I - Main model – Rheumatoid arthritis (n = 739 patients and 30,829 controls)¹

  Female gender

1.50

1.29 to 1.75

<0.01

  Age²

1.03

1.02 to 1.04

<0.001

  Current smoker

1.64

1.38 to 1.96

<0.001

  Former smoker

1.32

1.10 to 1.59

<0.01

  Hypertension

0.97

0.82 to 1.15

0.76

  Diabetes

1.34

0.83 to 2.18

0.23

  Body mass index²

1.04

1.02 to 1.06

<0.001

  Previous CV disease

1.52

1.11 to 2.07

<0.01

II - Alternative models (sensitivity analyses) - Rheumatoid arthritis

  A – After exclusion of patients with self-reported psoriasis (n = 573 patients and 30,829 controls)¹

  Previous CV disease³

1.70

1.23 to 2.36

0.001

  B – Including patients with hospital diagnosis of RA (n = 201 patients and 30,829 controls)¹

  Previous CV disease³

1.90

1.10 to 3.27

0.02

  C – Including patients with hospital diagnosis of RA after 1999 (n = 178 patients and 30,829 controls)¹

  Previous CV disease³

2.26

1.26 to 3.99

  D – Including patients with hospital diagnosis of RA after 2001 (n = 138 patients and 30,829 controls)¹

  Previous CV disease³

2.51

1.33 to 4.73

<0.01

  E – Including patients carrying the Shared Epitope (n = 313 patients and 30,829 controls)¹

  Previous CV disease³

1.76

1.13 to 2.74

0.01

  F – Including patients carrying the Shared Epitope and excluding patients with self-reported psoriasis (n = 257 patients and 30,829 controls)¹

  Previous CV disease³

1.96

1.24 to 3.10

<0.01

III - Model for osteoarthritis (n = 3,364 patients and 24,631 controls)¹

  Female gender

2.36

2.15 to 2.56

<0.001

  Age²

1.05

1.05 to 1.06

<0.001

  Current smoker

1.42

1.30 to 1.56

<0.001

  Former smoker

1.23

1.12 to 1.35

<0.001

  Diabetes

0.90

0.66 to 1.22

0.49

  Body mass index²

1.06

1.05 to 1.07

<0.001

  Previous CV disease

1.04

0.86 to 1.27

0.66