|
I - Main model – Rheumatoid arthritis (n = 739 patients and 30,829 controls)1
|
|
Female gender
|
1.50
|
1.29 to 1.75
|
<0.01
|
|
Age2
|
1.03
|
1.02 to 1.04
|
<0.001
|
|
Current smoker
|
1.64
|
1.38 to 1.96
|
<0.001
|
|
Former smoker
|
1.32
|
1.10 to 1.59
|
<0.01
|
|
Hypertension
|
0.97
|
0.82 to 1.15
|
0.76
|
|
Diabetes
|
1.34
|
0.83 to 2.18
|
0.23
|
|
Body mass index2
|
1.04
|
1.02 to 1.06
|
<0.001
|
|
Previous CV disease
|
1.52
|
1.11 to 2.07
|
<0.01
|
|
II - Alternative models (sensitivity analyses) - Rheumatoid arthritis
|
|
A – After exclusion of patients with self-reported psoriasis (n = 573 patients and 30,829 controls)1
|
|
Previous CV disease3
|
1.70
|
1.23 to 2.36
|
0.001
|
|
B – Including patients with hospital diagnosis of RA (n = 201 patients and 30,829 controls)1
|
|
Previous CV disease3
|
1.90
|
1.10 to 3.27
|
0.02
|
|
C – Including patients with hospital diagnosis of RA after 1999 (n = 178 patients and 30,829 controls)1
|
|
Previous CV disease3
| |
2.26
|
1.26 to 3.99
|
|
D – Including patients with hospital diagnosis of RA after 2001 (n = 138 patients and 30,829 controls)1
|
|
Previous CV disease3
|
2.51
|
1.33 to 4.73
|
<0.01
|
|
E – Including patients carrying the Shared Epitope (n = 313 patients and 30,829 controls)1
|
|
Previous CV disease3
|
1.76
|
1.13 to 2.74
|
0.01
|
|
F – Including patients carrying the Shared Epitope and excluding patients with self-reported psoriasis (n = 257 patients and 30,829 controls)1
|
|
Previous CV disease3
|
1.96
|
1.24 to 3.10
|
<0.01
|
|
III - Model for osteoarthritis (n = 3,364 patients and 24,631 controls)1
|
|
Female gender
|
2.36
|
2.15 to 2.56
|
<0.001
|
|
Age2
|
1.05
|
1.05 to 1.06
|
<0.001
|
|
Current smoker
|
1.42
|
1.30 to 1.56
|
<0.001
|
|
Former smoker
|
1.23
|
1.12 to 1.35
|
<0.001
|
|
Diabetes
|
0.90
|
0.66 to 1.22
|
0.49
|
|
Body mass index2
|
1.06
|
1.05 to 1.07
|
<0.001
|
|
Previous CV disease
|
1.04
|
0.86 to 1.27
|
0.66
|
