Table 1 Genotype and allele association analysis of seven single nucleotide polymorphisms (SNPs) in samples of AS in Shandong and rs1128334 in Ningxia
From: ETS1 variants confer susceptibility to ankylosing spondylitis in Han Chinese
Population | SNPs | Position | Genotype/allele | Patients, number (%) | Controls, number (%) | Odds ratio | 95% CI | P- value | P* |
|---|---|---|---|---|---|---|---|---|---|
rs12574073 | 128319478 | CC | 423 (42.7) | 401 (47.8) | 1 | ||||
CT | 457 (46.1) | 356 (41.8) | 1.217 | 1.002, 1.478 | 0.192 | ||||
TT | 111 (11.2) | 89 (10.4) | 1.182 | 0.867, 1.613 | |||||
C | 1,303 (65.7) | 1,170 (68.7) | 1 | ||||||
T | 679 (34.3) | 534 (31.3) | 1.142 | 0.994, 1.311 | 0.062 | ||||
rs1128334 | 128328959 | GG | 417 (42.2) | 528 (48.0) | 1 | ||||
AG | 457 (46.3) | 471 (42.8) | 1.229 | 1.024, 1.473 | 0.018 | ||||
AA | 114 (11.5) | 101 (9.2) | 1.429 | 1.062, 1.923 | |||||
G | 1,291 (65.3) | 1,527 (69.4) | 1 | ||||||
A | 685 (34.7) | 673 (30.6) | 1.204 | 1.058, 1.371 | 0.005 | 0.035 | |||
rs4937333 | 128330520 | TT | 183 (18.2) | 177 (15.6) | 1 | ||||
CT | 483 (48.0) | 535 (42.3) | 0.873 | 0.687, 1.111 | 0.160 | ||||
CC | 341 (33.8) | 420 (37.1) | 0.785 | 0.611, 1.010 | |||||
T | 849 (42.2) | 889 (39.3) | 1 | ||||||
C | 1165 (57.8) | 1375 (60.7) | 0.887 | 0.785, 1.003 | 0.057 | ||||
Shandong | rs4254089 | 128366221 | CC | 64 (6.3) | 66 (5.9) | 1 | |||
CT | 356 (35.1) | 365 (32.9) | 1.006 | 0.692, 1.461 | 0.478 | ||||
TT | 595 (58.6) | 680 (61.2) | 0.902 | 0.629, 1.295 | |||||
C | 484 (23.8) | 497 (22.4) | 1 | ||||||
T | 1546 (76.2) | 1725 (77.6) | 0.920 | 0.798, 1.062 | 0.259 | ||||
rs7951925 | 128379964 | AA | 84 (8.3) | 109 (9.7) | 1 | ||||
AG | 420 (41.4) | 444 (39.6) | 1.227 | 0.896, 1.681 | 0.433 | ||||
GG | 510 (50.3) | 569 (51.7) | 1.163 | 0.854, 1.584 | |||||
A | 588 (29.0) | 662 (29.5) | 1 | ||||||
G | 1,440 (71.0) | 1,582 (70.5) | 1.025 | 0.898, 1.169 | 0.736 | ||||
rs7116578 | 128388773 | AA | 869 (85.9) | 970 (86.3) | 1 | ||||
AG | 133 (13.1) | 145 (12.9) | 1.024 | 0.795, 1.318 | 0.884 | ||||
GG | 10 (1.0) | 9 (0.8) | 1.240 | 0.502, 3.066 | |||||
A | 1,871 (92.4) | 2,085 (92.7) | 1 | ||||||
G | 153 (7.6) | 163 (7.3) | 1.046 | 0.832, 1.316 | 0.726 | ||||
rs4937342 | 128398309 | TT | 903 (89.8) | 993 (90.2) | 1 | ||||
TG | 101 (10.0) | 102 (9.3) | 1.089 | 0.815, 1.455 | 0.368 | ||||
GG | 2 (0.2) | 6 (0.5) | 0.367 | 0.074, 1.821 | |||||
T | 1,907 (94.8) | 2,088 (94.8) | 1 | ||||||
G | 105 (5.2) | 114 (5.2) | 1.008 | 0.768, 1.324 | 1.000 | ||||
Ningxia | rs1128334 | 128328959 | GG | 135 (38.4) | 190 (47.5) | 1 | |||
AG | 168 (47.7) | 166 (41.5) | 1.424 | 1.047, 1.938 | 0.038 | ||||
AA | 49 (13.9) | 44 (11.0) | 1.576 | 0.986, 2.490 | |||||
G | 438 (62.2) | 546 (68.2) | 1 | ||||||
A | 266 (37.8) | 254 (31.8) | 1.305 | 1.055, 1.615 | 0.015 |