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Table 1 Revised classification criteria for anti-phospholipid syndrome[1]

From: Antiphospholipid syndrome in 2014: more clinical manifestations, novel pathogenic players and emerging biomarkers

Clinical criteria  
 Vascular thrombosis One or more episodes of arterial, venous or small vessel thrombosis in any tissue or organ (confirmed by objective validated criteria (imaging study or histopathology))
 Pregnancy complications One or more unexplained deaths of a morphologically normal fetus ≥10th gestational week
  One or more premature births (≤34th gestational week) of a morphologically normal neonate because of eclampsia, severe pre-eclampsia or placental insufficiency
  Three or more unexplained consecutive spontaneous abortions ≤9th gestational week (maternal anatomic and hormonal abnormalities and chromosomal abnormalities excluded)
Laboratory criteria  
 Lupus anticoagulant present in plasma Detected according to the guidelines of the International Society of Thrombosis and Haemostasis (Scientific subcommittee on lupus anticoagulant/phospholipid-dependent antibodies)
 IgG and/or IgM anti-cardiolipin antibodies in serum of plasma At medium/high titer (≥40 GPL or MPL or ≥99th percentile) measured by standard ELISA
 IgG and/or IgM anti-β2 glycoprotein I antibodies in serum or plasma Titer ≥99th percentile measured by standard ELISA, according to recommended procedures
  1. At least one clinical and one laboratory criterion is mandatory. Autoantibodies have to be confirmed on two or more occasions at least 12 weeks apart. ELISA, enzyme-linked immunosorbent assay; GPL, IgG aPL units; Ig, immunoglobulin; MPL, IgM aPL units.