Classification and characteristics of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis in a nationwide, prospective, inception cohort study

Table 2 Surrogate markers in nine patients who were classified with granulomatosis with polyangiitis using these markers

	Number of patients
	(MPO-ANCA/PR3-ANCA^a)
X-ray evidence of fixed pulmonary infiltrates, nodules, or cavitations present for >1 month	1 (1/0)
Bronchial stenosis	0 (0/0)
Bloody nasal discharge and crusting for 1 month or nasal ulceration	1^b (0/1)
Chronic sinusitis, otitis media, or mastoiditis for >3 months	7^c (4/5)
Retro-orbital mass or inflammation (pseudotumor)	0 (0/0)
Subglottic stenosis	1 (0/1)
Saddle nose deformity/destructive sinonasal disease	1 (0/1)

ANCA, antineutrophil cytoplasmic antibody; MPO, myeloperoxidase; PR3, proteinase-3. ^aMPO-ANCA/PR3-ANCA, anti-myeloperoxidase antibody-positive versus anti-proteinase-3 antibody-positive patients. ^bOne patient had bloody nasal discharge and crusting and chronic sinusitis, and another patient had subglottic stenosis and saddle nose deformity. ^cFive patients with chronic sinusitis, three patients with otitis media, and no patients with mastoiditis.