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Table 2 Genes of greatest potential functional relevance determined by network analysis

From: Network analysis identifies protein clusters of functional importance in juvenile idiopathic arthritis

 

JIA-associated genes with correlated expression data that lie within the minimal essential network (MEN)

Dapple P-value

RF-ve polyarticular JIA compared with controls

KSR1

0.0088

Oligoarticular JIA compared with controls

PTPN2

0.0112

Oligoarticular compared with RF-ve polyarticular JIA

STAT1

0.0002

  1. Genes present within the MEN which also show altered gene expression in either rheumatoid-negative (RF-ve) polyarticular juvenile idiopathic arthritis (JIA) compared with controls, oligoarticular JIA compared with controls, or between oligoarticular compared with RF-ve polyarticular JIA are listed. Presence in the MEN indicates functional priority and the Disease association protein-protein link evaluator (Dapple) P-value assesses the statistical significance of network connectivity compared to what would be expected by chance.
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Arthritis Research & Therapy

ISSN: 1478-6362

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