Figure 2From: Matrix assisted laser desorption ionization mass spectrometry imaging identifies markers of ageing and osteoarthritic cartilage Significant differential imaging of some ECM peptides. Biomap was used to localize and quantify the differences in the peptide peak intensity of m/z 1679.8, m/z 2256.1 and m/z 2027.2 between young, old and OA cartilages. Samples representative of each group are illustrated here. Scale bar shows normalized intensities to 190 m/z matrix peak. In the scale bar red represents the highest signal. Histograms show the means of the relative peak intensities and 95% CI, n = 3 for each peptide. There was no change in the distribution of the type II collagen peak m/z 1679.8. However, a significant difference was evident for the COMP peptide m/z 2256.1 (P = 0.03 young versus old and old versus OA) and the biglycan peptide m/z 2027.2 (P = 0.02, young versus OA and old versus OA). COMP, cartilage oligomeric matrix protein; ECM, extracellular matrix; OA, osteoarthritis; 95% CI, 95% confidence interval.Back to article page