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Table 2 The haplotype frequencies of NR1H3 gene

From: Liver X receptors alpha gene (NR1H3) promoter polymorphisms are associated with systemic lupus erythematosus in Koreans

Haplotype SLE NC SLE versus NC
   (n = 300) (n = 217) P value OR (95% CI)
HT1 +/+ 109 (36.3%) 103 (47.5%) co : 0.033 0.727 (0.542 ~ 0.974)
[TTGG] +/- 169 (56.3%) 99 (45.6%) do : 0.808 0.956 (0.681 ~ 1.349)
  -/- 22 (7.3%) 15 (6.9%) re : 0.012 0.796 (0.666 ~ 0.951)
HT2 +/+ 16 (5.3%) 15 (6.9%) co : 0.255 0.847 (0.636 ~ 1.128)
[CTGG] +/- 111 (37.0%) 87 (40.1%) do : 0.280 0.908 (0.761 ~ 1.082)
  -/- 173 (57.7%) 115 (53.0%) re : 0.507 0.884 (0.614 ~ 1.273)
HT3 +/+ 2 (0.7%) 0 (0.0%) co : 0.008 2.739 (1.304 ~ 5.751)
[TCGG] +/- 30 (10.0%) 9 (4.1%) do : 0.009 1.662 (1.134 ~ 2.435)
  -/- 268 (89.3%) 208 (95.9%) re : 0.999 36085.247 (0.000 ~ NA)
HT others +/+ 3 (1.0%) 0 (0.0%) co : <0.001 8.375 (2.557 ~ 27.431)
  +/- 30 (10.0%) 3 (1.4%) do : <0.001 2.984 (1.641 ~ 5.427)
  -/- 267 (89.0%) 214 (98.6%) re : 0.999 32475.263 (0.000 ~ NA)
  1. Haplotypes (HT) were analyzed using Haploview version 4.1 based on the EM algorithm. Each P value was calculated with co-dominant(co), dominant(do), and recessive(re) models. Logistic regression analysis was applied to control for age and sex as covariables. Two genetic polymorphisms of the NR1H3 gene, -840 C > A and -115 G > A, were in complete linkage disequilibrium. Therefore, -840 C > A was excluded in the haplotype analysis. CI, confidence interval; NA, not applicable; OR, odds ratio.