B cell subsets and dysfunction of regulatory B cells in IgG4-related diseases and primary Sjögren’s syndrome: the similarities and differences

Table 3 Serum cytokine levels in IgG4-RD, pSS patients and HC

	HC	IgG4-RD	pSS	IgG4-RD versus HC	pSS versus HC	IgG4-RD versus pSS
	(n = 24)	(n = 28)	(n = 28)	P- value	P- value	P- value
IL-4, pg/mL	1.69 ± 1.46	6.54 ± 5.67	6.52 ± 6.14	<0.001	<0.001	0.931
IL-5, pg/mL	1.34 ± 1.03	1.48 ± 1.51	2.23 ± 3.16	0.932	0.776	0.965
IL-6, pg/mL	0.68 ± 0.39	2.14 ± 1.66	1.35 ± 1.40	<0.001	0.002	0.009
IL-10, pg/mL	3.22 ± 1.40	10.67 ± 5.50	11.59 ± 7.90	<0.001	<0.001	0.697
IL-13, pg/mL	3.18 ± 2.61	3.99 ± 6.15	10.05 ± 13.99	0.524	0.016	0.013
IL-17A, pg/mL	0.24 ± 0.15	0.40 ± 0.57	1.10 ± 1.37	0.482	<0.001	0.001
IFN-γ, pg/mL	1.02 ± 0.81	2.23 ± 1.56	3.20 ± 3.15	0.002	0.002	0.493
TGF-β, ng/mL	17.73 ± 4.81	16.94 ± 7.73	14.16 ± 5.66	0.643	0.006	0.035
BAFF, ng/mL	0.70 ± 0.42	2.60 ± 2.80	2.31 ± 2.65	<0.001	<0.001	0.236

Values are shown as mean ± SD. IgG4-RD, IgG4-related disease; pSS, primary Sjögren’s syndrome; HC, healthy controls.

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