Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus

Table 3 Decreased expression of C5aR (CD88) on polymorphonuclear leukocytes (PMN) from patients with systemic lupus erythematosus (SLE)

Phenotype	Healthy blood donors	SLE patients	P-value
CD88, %	92 ± 3.8	77 ± 1	≤0.0001
CD88, geoMFI	466 ± 24	285 ± 4	≤0.0001
CD62L, %	98 ± 0.3	98 ± 0.2	ns
CD62L, geoMFI	1180 ± 64	1100 ± 42	ns
CD11b, %	100 ± 0	100 ± 0	ns
CD11b, geoMFI	9343 ± 578	8166 ± 270	ns

Comparisons were done between SLE patients and healthy blood donors in regard of the frequency (%) and amount (geometric mean fluorescence intensity (geoMFI) of positive cells) of CD88, CD62L and CD11b on CD10⁺CD16⁺ PMN. Values represent mean ± standard error of the mean. The two-sided Mann-Whitney test was used to calculate the level of significance; ns, not significant.

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