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Table 3 Decreased expression of C5aR (CD88) on polymorphonuclear leukocytes (PMN) from patients with systemic lupus erythematosus (SLE)

From: Low production of reactive oxygen species in granulocytes is associated with organ damage in systemic lupus erythematosus

Phenotype Healthy blood donors SLE patients P-value
CD88, % 92 ± 3.8 77 ± 1 ≤0.0001
CD88, geoMFI 466 ± 24 285 ± 4 ≤0.0001
CD62L, % 98 ± 0.3 98 ± 0.2 ns
CD62L, geoMFI 1180 ± 64 1100 ± 42 ns
CD11b, % 100 ± 0 100 ± 0 ns
CD11b, geoMFI 9343 ± 578 8166 ± 270 ns
  1. Comparisons were done between SLE patients and healthy blood donors in regard of the frequency (%) and amount (geometric mean fluorescence intensity (geoMFI) of positive cells) of CD88, CD62L and CD11b on CD10+CD16+ PMN. Values represent mean ± standard error of the mean. The two-sided Mann-Whitney test was used to calculate the level of significance; ns, not significant.