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Table 3 Comparisons of risk for acute coronary syndrome between study cohorts a

From: The risk of acute coronary syndrome in rheumatoid arthritis in relation to tumour necrosis factor inhibitors and the risk in the general population: a national cohort study

Cohort/risk window Biologic-naïve RA comparator   General population comparator  
  HR b(95% CI) HR c(95% CI) HR b(95% CI) HR c(95% CI)
TNFi-treated RA     
  Ever-exposed 0.81 (0.69 to 0.94) 0.82 (0.70 to 0.95) 1.93 (1.66 to 2.25) 1.61 (1.36 to 1.92)
  Actively on TNFi 0.71 (0.58 to 0.86) 0.73 (0.60 to 0.89) 1.73 (1.43 to 2.10) 1.50 (1.21 to 1.85)
  Short-term exposure 0.75 (0.58 to 0.97) 0.78 (0.61 to 1.01) 2.07 (1.59 to 2.70) 1.65 (1.23 to 2.22)
Biologic-naïve RA comparator     
  Ever-exposed 2.35 (2.11 to 2.63) 2.03 (1.80 to 2.29)
  Actively on TNFi 2.41 (2.11 to 2.76) 2.10 (1.82 to 2.43)
  Short-term exposure 2.63 (2.21 to 3.13) 2.27 (1.89 to 2.73)
  1. aHR, Hazard ratio; RA, Rheumatoid arthritis; TNFi, Tumour necrosis factor inhibitor. bModel adjusted for age, sex and county of residence. cModel stratified for disability pension during the year before inclusion and adjusted for sex; age at time of inclusion; county of residence; year of inclusion; previous joint surgery; previous diagnosis of diabetes, hypertension, chronic obstructive pulmonary disease, cerebrovascular disease or other atherosclerotic disease; previous hospitalization for infectious disease; RA disease duration longer than 10 years (biologic-naïve and TNFi comparison); total number of days in hospital during 10 years prior to inclusion; sick leave; and education level.