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Figure 7 | Arthritis Research & Therapy

Figure 7

From: The interaction between C5a and sphingosine-1-phosphate in neutrophils for antineutrophil cytoplasmic antibody mediated activation

Figure 7

Proposed working model for the interaction between C5a and sphingosine-1-phosphate (S1P) in antineutrophil cytoplasmic antibody (ANCA)-mediated neutrophils activation. Neutrophils are primed by C5a to express ANCA antigens at the cell surface and supernatant. ANCA antibodies interact with the ANCA antigens which result in primed-neutrophil activation. The ANCA-activated neutrophils release S1P that can further activate neutrophils. S1P receptor antagonist may attenuate C5a-primed neutrophils for ANCA induced activation.

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Arthritis Research & Therapy

ISSN: 1478-6362

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