Figure 5

Increased rolling and adhesion of leukocytes in cremaster muscle post-capillary venules (PCV) in sdc-3 null mice by intravital microscopy. (A) Significant increases in leukocyte rolling are observed in TNFα-stimulated sdc-3−/−mice when compared to either TNFα-stimulated wild-type (WT) or unstimulated syn-3−/−mice. Similarly, CXCL1 stimulation induces greater rolling in sdc-3−/−mice. (B) Similar increases in leukocyte adhesion are observed in TNFα- and CXCL1-stimulated sdc-3−/−mice. Data are means ± SEM, n = 3 to 6 mice per treatment. ^*P <0.05; ^**P <0.01. CXCL1, chemokine C-X-C ligand 1; TNFα, tumour necrosis factor alpha.