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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Targeting IL-6 by both passive or active immunization strategies prevents bleomycin-induced skin fibrosis

Figure 3

Tight skin-1 (Tsk-1) mice are not protected from skin fibrosis by MR16-1 treatment. (A, B) Tsk-1 mice showed increased hypodermal thickness compared with the pa/pa control mice. However, no difference was observed between Tsk-1 mice receiving either MR16-1 or the isotype control. (C) Tsk-1 mice showed increased hydroxyproline concentration compared with the pa/pa control mice. However, no difference was observed between Tsk-1 mice receiving either MR16-1 or the isotype control. pa/pa mice (control mice for Tsk-1 mice) were defined as 1.0, and all other results are normalized to this value. Bars represent median(Q1,Q3); 17 mice were used for these experiments (five pa/pa mice, four Tsk-1 mice treated with isotype control, and eight Tsk-1 mice treated with MR16-1). Ab, antibody; NS, not significant.

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Arthritis Research & Therapy

ISSN: 1478-6362

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