Figure 2

Representation of major physicochemical glucocorticoid interactions with components of the cellular membrane. Membrane glucocorticoid receptor (mGR)-mediated nongenomic effects together with cytosolic glucocorticoid receptor (cGR)-mediated genomic effects on nuclear glucocorticoid response elements (GRE) (including inhibition of the nuclear factor-κB complex (NF-κB)) and resultant protein synthesis that can cause increased expression of regulatory - including anti-inflammatory - proteins (transactivation) or decreased production of proinflammatory proteins (transrepression) [16]. GC, glucocorticoid; GR, glucocorticoid receptor.