Figure 1

Efficacy, pharmacokinetics, and antibody incidence of infliximab. Efficacy of infliximab as (a) monotherapy (closed symbols) and (b) in combination with methotrexate (open symbols) based on Paulus 20% criteria; infliximab 1 mg/kg (closed triangle ▲, open triangle △), infliximab 3 mg/kg (closed diamond ◆, open diamond ◇), infliximab 10 mg/kg (closed square ■, open square □), and placebo plus methotrexate (closed circle ●). Arrows indicate the infusion times of infliximab and placebo. (c) Pharmacokinetics of infliximab alone (closed symbols) or with methotrexate (open symbols); infliximab 1 mg/kg (closed triangle ▲, open triangle △) infliximab 3 mg/kg (closed diamond ◆, open diamond ◇), and infliximab 10 mg/kg (closed square ■, open square □). (d) Incidence of anti-infliximab antibodies; infliximab alone (closed symbols) and infliximab plus methotrexate (open symbols). Panels a, b, and c, adapted with permission from Maini et al. [10]; panel d, data from Maini et al. [10]. Copyright 1999. American College of Rheumatology.