Table 2 Characteristics of CD4+ T cells chronically exposed to tumour necrosis factor
1 | Upregulation of activation antigens such as CD69 |
2 | Induction of nondeletional, proliferative hyporesponsiveness |
3 | Suppression of cytokine production |
4 | Uncoupling of TCR signal transduction pathways |
5 | Repression of CD28 gene transcription |