Table 1 Matrix metalloproteinases (MMPs) and their substrates
MMP | Enzyme | Mr latent | Mr active | Known substrates |
MMP-1 | Interstitial collagenase (collagenase-1) | 55,000 | 45,000 | Collagens I, II, III, VII, VIII and X, gelatin, aggrecan, versican, proteoglycan link protein, casein, α1-proteinase inhibitor, α2-M, pregnancy zone protein, ovostatin, nidogen, MBP, proTNF, L-selectin, proMMP-2, proMMP-9 |
MMP-2 | Gelatinase A | 72,000 | 66,000 | Collagens I, IV, V, VII, X, XI and XIV, gelatin, elastin, fibronectin, aggrecan, versican, proteoglycan link protein, MBP, proTNF, α1-proteinase inhibitor, proMMP-9, proMMP-13 |
MMP-3 | Stromelysin-1 | 57,000 | 45,000 | Collagens III, IV, IX and X, gelatin, aggrecan, versican, perlecan, nidogen, proteoglycan link protein, fibronectin, laminin, elastin, casein, fibrinogen, antithrombin-III, α2M, ovostatin, α1-proteinase inhibitor, MBP, proTNF, proMMP-1, proMMP-7, proMMP-8, proMMP-9, proMMP-13 |
MMP-7 | Matrilysin-1 (PUMP-1) | 28,000 | 19,000 | Collagens IV and X, gelatin, aggrecan, proteoglycan link protein, fibronectin, laminin, entactin, elastin, casein, transferrin, MBP, α1-proteinase inhibitor, proTNF, proMMP-1, proMMP-2, proMMP-9 |
MMP-8 | Neutrophil collagenase | 75,000 | 58,000 | Collagens I, II, III, V, VII, VIII and X, gelatin, aggrecan, α1-proteinase (collagenase-2) inhibitor, α2-antiplasmin, fibronectin |
MMP-9 | Gelatinase B | 92,000 | 86,000 | Collagens IV, V, VII, X and XIV, gelatin, elastin, aggrecan, versican, proteoglycan link protein, fibronectin, nidogen, α1-proteinase inhibitor, MBP, proTNF |
MMP-10 | Stromelysin-2 | 57,000 | 44,000 | Collagens III, IV and V, gelatin, casein, aggrecan, elastin, proteoglycan link protein, fibronectin, proMMP-1, proMMP-8 |
MMP-11 | Stromelysin-3 | 51,000 | 44,000 | α1-proteinase inhibitor |
MMP-12 | Macrophage metalloelastase | 54,000 | 45,000/ 22,000 | Collagen IV, gelatin, elastin, α1-proteinase inhibitor, fibronectin, vitronectin, laminin, proTNF, MBP |
MMP-13 | Collagenase-3 | 60,000 | 48,000 | Collagens I, II, III and IV, gelatin, plasminogen activator inhibitor 2, aggrecan, perlecan, tenascin |
MMP-14 | MT1-MMP | 66,000 | 56,000 | Collagens I, II and III, gelatin, casein, elastin, fibronectin, laminin B chain, vitronectin, aggrecan, dermatan sulfate proteoglycan, MMP-2, MMP-13, proTNF |
MMP-15 | MT2-MMP | 72,000 | 60,000 | proMMP-2, gelatin, fibronectin, tenascin, nidogen, laminin |
MMP-16 | MT3-MMP | 64,000 | 52,000 | proMMP-2 |
MMP-17 | MT4-MMP | 57,000 | 53,000 | |
MMP-18 | Xenopus collagenase | 55,000 | 42,000 | |
MMP-19 | 54,000 | 45,000 | Collagen IV, gelatin, laminin, nidogen, tenascin, fibronectin, aggrecan, COMP | |
MMP-20 | Enamelysin | 54,000 | 22,000 | Amelogenin |
MMP-21 | XMMP (xenopus) | 70,000 | 53,000 | |
MMP-22 (MMP-27) | CMMP (chicken) | 52,000 | 43,000 | Gelatin, casein |
MMP-23 | CA-MMP | ? | ? | |
MMP-24 | MT5-MMP | 63,000 | 45,000 | proMMP-2, proMMP-9, gelatin |
MMP-25 | MT6-MMP, leukolysin | 56,000 | Collagen IV, gelatin, fibronectin, fibrin | |
MMP-26 | Matrilysin-2, endometase | 28,000 | Collagen IV, fibronectin, fibrinogen, gelatin, α1-proteinase inhibitor, proMMP-9 | |
MMP-28 | Epilysin | 59,000 (55,000) | Casein |