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Table 1 Matrix metalloproteinases (MMPs) and their substrates

From: Matrix metalloproteinases in arthritic disease

MMP Enzyme Mr latent Mr active Known substrates
MMP-1 Interstitial collagenase (collagenase-1) 55,000 45,000 Collagens I, II, III, VII, VIII and X, gelatin, aggrecan, versican, proteoglycan link protein, casein, α1-proteinase inhibitor, α2-M, pregnancy zone protein, ovostatin, nidogen, MBP, proTNF, L-selectin, proMMP-2, proMMP-9
MMP-2 Gelatinase A 72,000 66,000 Collagens I, IV, V, VII, X, XI and XIV, gelatin, elastin, fibronectin, aggrecan, versican, proteoglycan link protein, MBP, proTNF, α1-proteinase inhibitor, proMMP-9, proMMP-13
MMP-3 Stromelysin-1 57,000 45,000 Collagens III, IV, IX and X, gelatin, aggrecan, versican, perlecan, nidogen, proteoglycan link protein, fibronectin, laminin, elastin, casein, fibrinogen, antithrombin-III, α2M, ovostatin, α1-proteinase inhibitor, MBP, proTNF, proMMP-1, proMMP-7, proMMP-8, proMMP-9, proMMP-13
MMP-7 Matrilysin-1 (PUMP-1) 28,000 19,000 Collagens IV and X, gelatin, aggrecan, proteoglycan link protein, fibronectin, laminin, entactin, elastin, casein, transferrin, MBP, α1-proteinase inhibitor, proTNF, proMMP-1, proMMP-2, proMMP-9
MMP-8 Neutrophil collagenase 75,000 58,000 Collagens I, II, III, V, VII, VIII and X, gelatin, aggrecan, α1-proteinase (collagenase-2) inhibitor, α2-antiplasmin, fibronectin
MMP-9 Gelatinase B 92,000 86,000 Collagens IV, V, VII, X and XIV, gelatin, elastin, aggrecan, versican, proteoglycan link protein, fibronectin, nidogen, α1-proteinase inhibitor, MBP, proTNF
MMP-10 Stromelysin-2 57,000 44,000 Collagens III, IV and V, gelatin, casein, aggrecan, elastin, proteoglycan link protein, fibronectin, proMMP-1, proMMP-8
MMP-11 Stromelysin-3 51,000 44,000 α1-proteinase inhibitor
MMP-12 Macrophage metalloelastase 54,000 45,000/ 22,000 Collagen IV, gelatin, elastin, α1-proteinase inhibitor, fibronectin, vitronectin, laminin, proTNF, MBP
MMP-13 Collagenase-3 60,000 48,000 Collagens I, II, III and IV, gelatin, plasminogen activator inhibitor 2, aggrecan, perlecan, tenascin
MMP-14 MT1-MMP 66,000 56,000 Collagens I, II and III, gelatin, casein, elastin, fibronectin, laminin B chain, vitronectin, aggrecan, dermatan sulfate proteoglycan, MMP-2, MMP-13, proTNF
MMP-15 MT2-MMP 72,000 60,000 proMMP-2, gelatin, fibronectin, tenascin, nidogen, laminin
MMP-16 MT3-MMP 64,000 52,000 proMMP-2
MMP-17 MT4-MMP 57,000 53,000  
MMP-18 Xenopus collagenase 55,000 42,000  
MMP-19   54,000 45,000 Collagen IV, gelatin, laminin, nidogen, tenascin, fibronectin, aggrecan, COMP
MMP-20 Enamelysin 54,000 22,000 Amelogenin
MMP-21 XMMP (xenopus) 70,000 53,000  
MMP-22 (MMP-27) CMMP (chicken) 52,000 43,000 Gelatin, casein
MMP-23 CA-MMP ? ?  
MMP-24 MT5-MMP 63,000 45,000 proMMP-2, proMMP-9, gelatin
MMP-25 MT6-MMP, leukolysin   56,000 Collagen IV, gelatin, fibronectin, fibrin
MMP-26 Matrilysin-2, endometase 28,000   Collagen IV, fibronectin, fibrinogen, gelatin, α1-proteinase inhibitor, proMMP-9
MMP-28 Epilysin 59,000 (55,000)   Casein
  1. α2-M, α2-macroglobulin; COMP, cartilage oligomeric matrix protein; MBP, myelin basic protein; Mr, relative molecular mass; TNF, tumour necrosis factor.