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Table 1 Chemotactic activity of aminoacyl tRNA synthetases

From: Chemokine receptors on dendritic cells promote autoimmune reactions

Leukocyte subpopulation

HisRS

MHRS

1–48 HisRS

AsnRS

SerRS

AspRS

LysRS

Neutrophils

-

-

-

-

-

-

-

Monocytes

-

-

-

-

-

-

-

IL-2-activated monocytes

+

-

+

N.D.

N.D.

N.D.

N.D.

Lymphocytes

+

-

+

+

+

±

±

CD8 T cells

±

-

±

N.D.

N.D.

N.D.

N.D.

CD4 T cells

+

-

+

+

N.D.

N.D.

N.D.

iDCs

+

-

+

+

-

+

-

mDCs

-

-

-

-

N.D.

N.D.

N.D.

  1. -, absent response; +, positive response; ±, variable response; N.D., not done. AsnRS, asparaginyl tRNA synthetase; AspRS, aspartyl tRNA synthetase; HisRS, histidyl tRNA synthetase; iDC, immature dendritic cells; LysRS, lysyl tRNA synthetase; mDCs, mature dendritic cells; MHRS, mutated HisRS; SerRS, seryl tRNA synthetase.
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Arthritis Research & Therapy

ISSN: 1478-6362

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