Figure 1

IFN-γ responses following immunization with HCgp-39 protein. The IFN-γ responses of four different DR*0401 transgenic mice immunized with recombinant HCgp-39 in incomplete Freund's adjuvant following in vitro re-stimulation with either intact protein or immunodominant peptide epitope 322–337. (b) IFN-γ responses following immunization with peptide 322–337. The contrasting IFN-γ responses elicited by either intact protein antigen or peptide 322–337 after immunization of four similar DR*0401 mice with the synthetic peptide 322–377 itself.