From: Susceptibility genes in the pathogenesis of murine lupus
Model [reference]
Affected function
Fas [42], FasL [43], Bcl2[44]
Regulation of apoptosis
Sap [25], C1q [26], C4 [27], DNAse [28]
Clearance of antigen, such as apoptotic bodies and DNA
Ctla-4 [30], p21 [32], PD-1 [33], Lyn [38–40], Fyn [41]
Activation and regulation of T cells
BLyS [35–37], PD-1 [33], Lyn [38–40], Fyn [41], FcγRIIB [51]
Activation and regulation of B cells
FcγRIII [53], ICAM-1 [46]
Proinflammatory mechanisms
