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Table 1 Synthetic murine models of lupus

From: Susceptibility genes in the pathogenesis of murine lupus

Model [reference] Affected function
Fas [42], FasL [43], Bcl2[44] Regulation of apoptosis
Sap [25], C1q [26], C4 [27], DNAse [28] Clearance of antigen, such as apoptotic bodies and DNA
Ctla-4 [30], p21 [32], PD-1 [33], Lyn [3840], Fyn [41] Activation and regulation of T cells
BLyS [3537], PD-1 [33], Lyn [3840], Fyn [41], FcγRIIB [51] Activation and regulation of B cells
FcγRIII [53], ICAM-1 [46] Proinflammatory mechanisms
  1. BLyS, B-lymphocyte stimulator; FasL, Fas ligand; ICAM-1, intracellular adhesion molecule-1.