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Table 3 Intra-articular effects of various genes following direct delivery to the synovial lining of rabbit knees with antigen-induced arthritis

From: Lessons learned from gene transfer approaches

  Effect*
     Cartilage
Gene Edema Synovitis WBC Synthesis Degn
IL-1Ra 0 0/- - NT -
TNFRa 0 0 0/- NT 0
IL-1Ra + TNFRa - - - NT -
vIL-10 - - - + -
IGF-1 0 0 0 + 0
  1. *0, No effect; -, inhibition; +, stimulation; NT, nottested; WBC, white blood cell infiltrate into the synovial fluid;Degn, degradation; IL-1Ra, interleukin-1 receptorantagonist; TNFRa, tumor necrosis factor receptor antagonist; vIL-10, viralinterleukin-10; IGF, insulin-like growth factor.