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Table 3 Intra-articular effects of various genes following direct delivery to the synovial lining of rabbit knees with antigen-induced arthritis

From: Lessons learned from gene transfer approaches

 

Effect*

    

Cartilage

Gene

Edema

Synovitis

WBC

Synthesis

Degn

IL-1Ra

0

0/-

-

NT

-

TNFRa

0

0

0/-

NT

0

IL-1Ra + TNFRa

-

-

-

NT

-

vIL-10

-

-

-

+

-

IGF-1

0

0

0

+

0

  1. *0, No effect; -, inhibition; +, stimulation; NT, nottested; WBC, white blood cell infiltrate into the synovial fluid;Degn, degradation; IL-1Ra, interleukin-1 receptorantagonist; TNFRa, tumor necrosis factor receptor antagonist; vIL-10, viralinterleukin-10; IGF, insulin-like growth factor.
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Arthritis Research & Therapy

ISSN: 1478-6362

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