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Table 1 Peptide sequences and predicted DR4 binding scores

From: The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model

Peptide source Sequence DR4 binding score
hCII (261–273) AGFKGEQGPKG EP 1.5
hCII (316–333) GFPFQDFLAF PKGAPGER -0.5
hAG (280–292) AGWLADRSVRY PI 4.1
hAG (1786–1798) GAYYGSGTPSS FP 5.4
HBsAg (16–33) YQAGFFLLTRILTI PQSLD 3.1
HBsAg (94–106) LLVLLDYQGML PV -1.1
HBsAg (159–171) AKYLWEWASVR FS 0.8
HBsAg L23A GFFLATRILTI PQ 2.1
HBsAg L23A/T28R GFFLATRILRI PQ 2.3
  1. Peptide sequences are shown from amino-terminus to carboxyl-terminus. Underlined amino acids indicate the predicted residues that interact with the MHC binding groove from P1 to P9. DR4 binding scores were calculated according to the method of Hammer et al. [11]. hCII, human type II collagen; hAG, human aggrecan; HBsAg, hepatitis B surface antigen.