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Table 1 Peptide sequences and predicted DR4 binding scores

From: The relationship between predicted peptide–MHC class II affinity and T-cell activation in a HLA-DRβ1*0401 transgenic mouse model

Peptide source

Sequence

DR4 binding score

hCII (261–273)

AGFKGEQGPKG EP

1.5

hCII (316–333)

GFPFQDFLAF PKGAPGER

-0.5

hAG (280–292)

AGWLADRSVRY PI

4.1

hAG (1786–1798)

GAYYGSGTPSS FP

5.4

HBsAg (16–33)

YQAGFFLLTRILTI PQSLD

3.1

HBsAg (94–106)

LLVLLDYQGML PV

-1.1

HBsAg (159–171)

AKYLWEWASVR FS

0.8

HBsAg L23A

GFFLATRILTI PQ

2.1

HBsAg L23A/T28R

GFFLATRILRI PQ

2.3

  1. Peptide sequences are shown from amino-terminus to carboxyl-terminus. Underlined amino acids indicate the predicted residues that interact with the MHC binding groove from P1 to P9. DR4 binding scores were calculated according to the method of Hammer et al. [11]. hCII, human type II collagen; hAG, human aggrecan; HBsAg, hepatitis B surface antigen.
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Arthritis Research & Therapy

ISSN: 1478-6362

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