Figure 5
From: The VH gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus
Clonal genealogical trees constructed from sequence data from germinal centre (GC) A, GC B and cluster C. Numbers in bold indicate the minimum number of mutations required between each sequence. The bracketed figures represent silent mutations. The dashed circle shown in cluster C represents a hypothetical intermediate that was not actually found among the sequences. GC A contained two highly mutated B cell clones represented as (a) and (b).