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Table 3 Major histocompatibility complex class II associations with autoantibodies seen in patients with SSc

From: The clinical relevance of autoantibodies in scleroderma

Autoantibodies HLA association Comments References
ACA HLA-DRB1   
     DRB1*01 In Hispanics and Caucasians [5355]
     DRB1*04   
  HLA-DQB1   
     DQB1*05   [53, 55]
Anti-Scl-70 HLA-DRB1   
     DRB1*1101 In Caucasians and African Americans [5355]
     DRB1*1104 In Japanese [53, 55]
     DRB1*1502 In Hispanics and Caucasians [55, 136]
  HLA-DQB1   
     DQB1*0301   [71]
     DQB1*0601   
  HLA-DPB1   
     DPB1*1301 In Caucasians [55]
     DPB1*0901 In Japanese [136]
Anti-PM-Scl HLA-DQA1*0501 Not seen in Japanese [54, 80]
  HLA-DRB1*0301   
Anti-Th/To HLA-DRB1*11   [87]
Anti-RNAP HLA-DQB1*0201 ?   [91, 93]
  No association   
Anti-U1-RNP HLA-DR2 In Japanese and Caucasians [117]
  HLA-DR4   
  HLA-DQw5 In African Americans [118]
     DQA1*0101   
     DQB1*0501   
  HLA-DQw8   
     DQB1*0302   
Anti-U3-RNP/antifibrillarin antibodies HLA-DQB1*0604 ?   [91, 93]
  No association   
  1. Question marks denote associations seen in one study but not confirmed elsewhere. ACA, anti-centromere antibodies; HLA, human leukocyte antigen; RNP, ribonucleoprotein.