The clinical relevance of autoantibodies in scleroderma

Table 3 Major histocompatibility complex class II associations with autoantibodies seen in patients with SSc

Autoantibodies	HLA association	Comments	References
ACA	HLA-DRB1
	DRB101*	In Hispanics and Caucasians	[53–55]
	DRB104*
	HLA-DQB1
	DQB105*		[53, 55]
Anti-Scl-70	HLA-DRB1
	DRB11101*	In Caucasians and African Americans	[53–55]
	DRB11104*	In Japanese	[53, 55]
	DRB11502*	In Hispanics and Caucasians	[55, 136]
	HLA-DQB1
	DQB10301*		[71]
	DQB10601*
	HLA-DPB1
	DPB11301*	In Caucasians	[55]
	DPB10901*	In Japanese	[136]
Anti-PM-Scl	HLA-DQA10501*	Not seen in Japanese	[54, 80]
	HLA-DRB10301*
Anti-Th/To	HLA-DRB1*11		[87]
Anti-RNAP	HLA-DQB10201* ?		[91, 93]
	No association
Anti-U1-RNP	HLA-DR2	In Japanese and Caucasians	[117]
	HLA-DR4
	HLA-DQw5	In African Americans	[118]
	DQA10101*
	DQB10501*
	HLA-DQw8
	DQB10302*
Anti-U3-RNP/antifibrillarin antibodies	HLA-DQB10604* ?		[91, 93]
	No association

Question marks denote associations seen in one study but not confirmed elsewhere. ACA, anti-centromere antibodies; HLA, human leukocyte antigen; RNP, ribonucleoprotein.

ISSN: 1478-6362