The clinical relevance of autoantibodies in scleroderma

Table 4 Sensitivity and specificity of Anti-Scl-70 in diagnosis of SSc

SSc versus:	Assay used	Sensitivity (%)	Specificity (%)
Normal controls	ID	20*	100*
	IB	41*	99.4*
	ELISA	43*	100*
	Overall	34^†	99.6^†
Other connective tissue diseases	ID	26*	99.5*
	IB	40*	99*
	ELISA	43*	90*
	Overall		97.9^†
Primary Raynaud's phenomenon	ID	28*	98*
Non-SSc relatives	ID	25.5*	100* ^†

*Reference [35]. ^†Reference [36]. ELISA, enzyme-linked immunosorbent assay; IB, immunoblotting; ID, immunodiffusion.

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