Figure 2From: Activation of synovial fibroblasts in rheumatoid arthritis: lack of expression of the tumour suppressor PTEN at sites of invasive growth and destructionIn situ hybridization on rheumatoid arthritis synovialtissue shows only negligible expression of PTEN in the lining layer (A) but abundant expression in the sublining layer (A, B). Normal synoviumconsisting of only two to three cell layers of synovial cells showed clearstaining, both in the most superficial layers and in deeper regions (C).The sense probe gave no specific staining (D).Back to article page