Figure 3

Rheumatoid arthritis (RA) patients with disease-associated human leucocyte antigen (HLA) genotypes had a higher relative reactivity to CII than RA patients with other HLA genotypes. Purified protein derivative (PPD) compensated IFN-γ production in response to denatured type II collagen are shown: (a) HLA-DRB1^*0401-positive (n =13) or DRB1^*0401-negative (n = 32) RA patients and healthy control individuals (n = 9 and 15, respectively); and (b) HLA-DQA1^*0301-DQB1^*0301 (HLA-DQ8)-positive (n = 15) and HLA-DQ8 negative (n = 30) RA patients and healthy control (HC) individuals (n =5 and 15, respectively). The box plots show the median as a line and the 25th and 75th centiles limiting the box, with the 10th and 90th centiles indicated with bars.