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Table 2 CII-induced IFN-γ response is major histocompatibility Complex (MHC) class II restricted

From: IFN-γ production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1*0401 and HLA-DQ8

  No ab Class II ab Control ab
CII 100 10 (6–22) 75 (66–125)
PPD 100 13 (8–32) 109 (63–123)
influenza 100 7 (4–15) 95 (68–125)
  1. Peripheral blood mononuclear cells from two rheumatoid arthritis Patients and three healthy controls were stimulated with native Collagen type II (CII), influenza virus or purified protein derivative in the Presence of antibodies (ab) specific for major histocompatibility Complex-class II or isotype-matched control antibodies. Supernatants Were collected after 7 days of culture and the concentration of IFN-γ was analysed by enzyme-linked immunosorbent assay. Values are expressed as median % (range) of cytokine present in Supernatants of which no antibodies were added.