Figure 1
Adenovirus-mediated transforming growth factor (TGF)-β1 gene expression in naïve and antigen-induced arthritis (AIA) rabbit joints. (A) 1 × 107, 1 × 108 and 1 × 109 adenoviral particles encoding human TGF-β1 cDNA were injected into naïve rabbit left knees. (B) 1 × 109 viral particles were injected into naïve rabbit left knees. (C) 1 × 108 and 1 × 109 viral particles were injected into AIA rabbit left knees. The same amounts of control viral particles were injected into the contralateral knees. Levels of TGF-β1 are expressed in nanograms per milliliter of lavage fluid recovered from knees 3, 7 and 17 days postinfection. All values are expressed as mean ± standard error of the mean.