Figure 5
Histological analyses of synovial tissue recovered from rabbit knees joints and muscular tissue adjacent to the joints. (A, B) Naïve rabbit left knees were injected with 1 × 109 adenoviral vector expressing human transforming growth factor beta 1 (Ad.TGF-β1) viral particles. (C, D) The contralateral knee joint of (A, B). (E, F) Long-term naïve rabbit left knees were injected with 1 × 109 Ad.TGF-β1 viral particles. (G, H) The contralateral knee joint of (E, F). (I, J) Antigen-induced arthritis rabbit knees were injected with 1 × 109 Ad.TGF-β1 viral particles. (K, L) The contralateral knee of (I, J). (M, N) Muscle from an adjacent naïve rabbit knee with 1 × 109 Ad.TGF-β1 viral particles. (O, P) The contralateral knee of (M, N). (B), (F), (J), and (N) High magnification (400 ×) images of (A), (E), (I), and (M) (100 ×), respectively. (D), (H), (L), and (P) High magnification (400 ×) images of (C), (G), (K), and (O) (100 ×), respectively.