Table 3 Deregulated genes in the arthritic synovial fibroblast as revealed by DNA microarrays
From: Functional analysis of an arthritogenic synovial fibroblast
Fold change | Â | Â | Â | |
|---|---|---|---|---|
A | B | P a | Gene ID | Accesion no. |
25 | 20 | 0.099 | peroxisome proliferator activated protein-gamma-2 | U09138 |
14 | 20 | 0.119 | c-erbA alpha2 for thyroid hormone receptor | X07751 |
17 | 16 | 0.000 | clusterin | L08235 |
12 | 12 | 0.085 | matricin | L20509 |
8 | 13 | 0.031 | laminin B1 | M15525 |
8 | 10 | 0.064 | RNA-binding protein AUF1 | U11274 |
11 | 7 | 0.304 | ribosomal protein L41 | U93862 |
9 | 8 | 0.065 | type II DNA topoisomerase beta isoform | D38046 |
8 | 8 | 0.122 | ZO-1 | D14340 |
7 | 6 | 0.012 | Ca2+-dependent activator protein for secretion | D86214 |
8 | 5 | 0.317 | ryanodine receptor type 3 | X83934 |
4 | 8 | 0.051 | serine/threonine-protein kinase PRP4m (PRP4m) | U48737 |
5 | 6 | 0.038 | multifunctional aminoacyl-tRNA synthetase | AA048927 |
6 | 5 | 0.017 | p53-associated cellular protein PACT | U28789 |
5 | 6 | 0.021 | alpha-adaptin (C) | X14972 |
5 | 5 | 0.007 | splicing factor; arginine/serine-rich 7 (SFRS7) | AA408185 |
5 | 5 | 0.053 | Y box transcription factor (MSY-1) | M62867 |
5 | 5 | 0.014 | ASF | X66091 |
4 | 6 | 0.053 | stromelysin PDGF responsive element binding protein transcription factor | U20282 |
6 | 4 | 0.127 | translation initiation factor (Eif4g2) | U63323 |
5 | 4 | 0.153 | ubiquitin-conjugating enzyme UbcM2 | AF003346 |
5 | 4 | 0.065 | DNA topoisomerase I | D10061 |
6 | 3 | 0.082 | calcyclin | M37761 |
5 | 4 | 0.055 | activin receptor (ActR) | M65287 |
5 | 3 | 0.112 | putative RNA helicase and RNA dependent ATPase (mDEAH9) | AF017153 |
3 | 5 | 0.051 | small nuclear RNA (Rnu1a-1) | L15447 |
-5 | -3 | 0.014 | gC1qBP gene | AJ001101 |
-5 | -3 | 0.013 | primase small subunit | D13544 |
-5 | -3 | 0.071 | T-cell specific protein s | L38444 |
-5 | -3 | 0.064 | complement receptor (Crry) gene | M34173 |
-2 | -6 | 0.168 | primary response gene B94 | L24118 |
-5 | -3 | 0.033 | ferritin L-subunit | L39879 |
-2 | -6 | 0.414 | C/EBP delta | X61800 |
-5 | -4 | 0.092 | tropomyosin isoform 2 | M22479 |
-6 | -3 | 0.136 | serine proteinase inhibitor (SPI3) | U25844 |
-7 | -2 | 0.145 | interferon beta (type 1) | V00755 |
-3 | -6 | 0.019 | TSC-22 mRNA | X62940 |
-3 | -7 | 0.013 | novel GTP-binding protein | D10715 |
-4 | -6 | 0.039 | core-binding factor | L03279 |
-8 | -2 | 0.125 | G-protein-like LRG-47 | U19119 |
-5 | -5 | 0.016 | SIG41 | X80232 |
-5 | -5 | 0.017 | BAP31 | X81816 |
-6 | -5 | 0.000 | Rat translational initiation factor (eIF-2) alpha subunit | AA408104 |
-3 | -8 | 0.048 | latent TGF-beta binding protein-2 | AF004874 |
-7 | -4 | 0.011 | endothelial monocyte-activating polypeptide I | U41341 |
-7 | -4 | 0.007 | beta proteasome subunit (Lmp3) | U65636 |
-7 | -4 | 0.075 | histone H2A.Z (H2A.Z) | U70494 |
-9 | -3 | 0.029 | NAD-dependent methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase | J04627 |
-7 | -5 | 0.059 | fibrillin (Fbn-1) | L29454 |
-7 | -5 | 0.031 | calumenin | U81829 |
-8 | -4 | 0.023 | TIMP-3 gene for metalloproteinase-3 tissue inhibitor | Z30970 |
-7 | -5 | 0.006 | Cctb mRNA for CCT (chaperonin containing TCP-1) beta subunit | Z31553 |
-7 | -6 | 0.036 | Nedd5 mRNA for DIFF6- or CDC3,10,11,12-like | D49382 |
-8 | -5 | 0.060 | cadherin-associated protein (CAP102/alpha catenin) | D90362 |
-9 | -4 | 0.338 | OTS-8 | M73748 |
-7 | -6 | 0.183 | 20S proteasome subunit Lmp7 (Lmp7d allele) | U22031 |
-5 | -8 | 0.202 | ornithine aminotransferase | X64837 |
-4 | -10 | 0.050 | Chromosome segregation protein CUT3 | AA241064 |
-7 | -7 | 0.183 | small heat-shock protein (HSP25) | L07577 |
-5 | -9 | 0.009 | triosephosphate isomerase | X53333 |
-10 | -4 | 0.024 | Sec61 protein complex gamma subunit | U11027 |
-9 | -5 | 0.010 | SPARC | X04017 |
-11 | -4 | 0.025 | Mer | D73368 |
-8 | -7 | 0.002 | IFN-gamma induced (Mg11) | U15635 |
-15 | -2 | 0.129 | lysyl oxidase | L04262 |
-9 | -8 | 0.100 | proteasome (lmp2) | L11613 |
-13 | -4 | 0.059 | DNA topoisomerase II | D12513 |
-9 | -9 | 0.006 | cytochrome c gene (MC1) | X01756 |
-12 | -6 | 0.004 | destrin | W08453 |
-12 | -7 | 0.027 | deleted in split hand/split foot 1 homologue (Dss1) | U41626 |
-13 | -7 | 0.013 | adenine nucleotide translocase-1 (Ant1) | U27315 |
-18 | -2 | 0.215 | major excreted protein (MEP). | X06086 |
-15 | -5 | 0.137 | osteopontin | X51834 |
-11 | -11 | 0.075 | integral membrane phosphoprotein band | U17297 |
-18 | -4 | 0.027 | phosphatase 2A B' alpha3 regulatory subunit | U59418 |
-11 | -11 | 0.038 | p85SPR | U96634 |
-12 | -11 | 0.036 | ubiquitinating enzyme E2-20K | U19854 |
-11 | -12 | 0.006 | brain factor-1 (Hfhbf1) | U36760 |
-13 | -11 | 0.072 | synaptonemal complex protein Sc65 | AA028785 |
-12 | -12 | 0.009 | mevalonate pyrophosphate decarboxylase | AA059528 |
-14 | -11 | 0.061 | MO15-associated kinase (MO15) | U11822 |
-12 | -13 | 0.031 | overexpressed and amplified in teratocarcinoma cell line ECA39 | X17502 |
-13 | -12 | 0.109 | DNA-polymerase delta catalytic subunit. | Z21848 |
-12 | -14 | 0.114 | alanyl-tRNA synthetase | AA254996 |
-15 | -11 | 0.035 | pituitary tumor-specific transforming factor | AA711028 |
-19 | -7 | 0.041 | neural precursor mRNA | D85414 |
-15 | -11 | 0.107 | protective protein (Mo54) | J05261 |
-15 | -11 | 0.044 | C57BL/6 Ly-49D-GE antigen | U10090 |
-12 | -15 | 0.169 | histone H2A.Z | AA285607 |
-11 | -16 | 0.031 | bcl-2 binding protein BAG-1 | U17162 |
-17 | -11 | 0.005 | antigen (homologue of human CD9 antigen) | C80730 |
-18 | -10 | 0.002 | adenine nucleotide translocase-1 (Ant1) | U27315 |
-18 | -11 | 0.080 | laminin | J02870 |
-14 | -15 | 0.036 | protective protein (Mo54) | J05261 |
-11 | -18 | 0.210 | keratinocyte lipid-binding protein | X70100 |
-14 | -16 | 0.253 | manganese superoxide dismutase (MnSOD) | X04972 |
-12 | -18 | 0.155 | MyD118, a myeloid differentiation primary response gene | X54149 |
-15 | -16 | 0.007 | glutamate dehydrogenase | X57024 |
-14 | -18 | 0.505 | cytosolic aspartate aminotransferase isoenzyme1 | J02623 |
-16 | -16 | 0.010 | voltage-dependent anion channel 1 mRNA | U30840 |
-17 | -15 | 0.059 | fractalkine | U92565 |
-17 | -15 | 0.044 | alpha glucosidase II beta subunit | U92794 |
-15 | -17 | 0.038 | glutamate dehydrogenase. | X57024 |
-21 | -12 | 0.069 | p53 cellular tumor antigen | K01700 |
-19 | -14 | 0.020 | bcl-2 binding protein BAG-1 | U17162 |
-22 | -12 | 0.051 | FKBP65 binding protein mRNA, complete cds | L07063 |
-18 | -16 | 0.022 | hepatoma transmembrane kinase ligand | L38847 |
-19 | -16 | 0.022 | hypothetical E. coli protein | AA271603 |
-23 | -12 | 0.091 | talin | X56123 |
-24 | -12 | 0.086 | alpha-1 type IV collagen (Col4a-1) | J04694 |
-19 | -17 | 0.007 | S-adenosyl homocysteine hydrolase (ahcy) | L32836 |
-16 | -20 | 0.054 | UBcM4 protein | X97042 |
-21 | -16 | 0.098 | cadherin-11 | AA184551 |
-17 | -20 | 0.012 | YL-1 protein | D43643 |
-23 | -14 | 0.199 | alpha-B crystallin | M63170 |
-23 | -14 | 0.155 | TDAG51 | U44088 |
-18 | -19 | 0.088 | chop-10 | X67083 |
-21 | -17 | 0.033 | 3-oxoacyl-CoA thiolasee | C79215 |
-23 | -15 | 0.171 | alpha-B2-crystallin | M73741 |
-23 | -15 | 0.134 | reduced folate carrier (RFC1) | U32469 |
-28 | -11 | 0.079 | Ubiquinol-cytochrome C reductase complex 6.4 KD protein | AA198790 |
-27 | -13 | 0.255 | epimorphin | D10475 |
-22 | -18 | 0.004 | alpha-2 type IV collagen | J04695 |
-21 | -19 | 0.027 | acrogranin | M86736 |
-29 | -11 | 0.013 | endogenous murine leukemia virus modified polytropic provirus DNA | M17327 |
-20 | -20 | 0.023 | C3H cytochrome P450 (Cyp1b1) | U03283 |
-21 | -21 | 0.005 | delta-aminolevulinate dehydratase | X13752 |
-22 | -21 | 0.058 | U1 snRNP-specific protein C | U70315 |
-27 | -16 | 0.058 | HN1 | U90123 |
-28 | -17 | 0.145 | mMIS5 | D86726 |
-37 | -11 | 0.104 | proteasome subunit MECL1. | D85561 |
-22 | -26 | 0.063 | growth factor-induced delayed early response protein | L02914 |
-21 | -27 | 0.121 | TAP2-d | U60087 |
-27 | -23 | 0.007 | RNA polymerase I 40 kD subunit | D31966 |
-16 | -34 | 0.212 | Ma | X62742 |
-38 | -13 | 0.282 | argininosuccinate synthetase (Ass) | M31690 |
-31 | -22 | 0.087 | Gas 5 growth arrest specific protein | X59728 |
-27 | -26 | 0.006 | mama | X67809 |
-26 | -27 | 0.031 | Cctz mRNA for CCT (chaperonin containing TCP-1) zeta | Z31557 |
-34 | -20 | 0.185 | hypothetical 28.4 KD protein | AA617493 |
-22 | -37 | 0.148 | H2-M alpha, H2-M beta 2, H2-M beta 1, Lmp2 | U35323 |
-39 | -35 | 0.056 | metaxin | L36962 |
-41 | -39 | 0.060 | Ubiquinol-cytochrome C reductase complex 7.2 KD protein | AA237529 |
-49 | -43 | 0.022 | hypothetical 26.5 KD protein | AA122622 |