Death, autoantigen modifications, and tolerance

Utz,, Paul J; Gensler, Timothy J; Anderson, Paul

doi:10.1186/ar75

Arthritis Research & Therapy

Table 2 Other death-associated autoantigen modifications

From: Death, autoantigen modifications, and tolerance

Autoantigen	Function	Modification	Disease	Reference
Actin	Cytoskeleton	Transglutamination	Autoimmune Hepatitis	[58,95,114]
DNA/nucleosome	Genetic code	DNA cleavage	SLE	[18*,19,30]
		DNA methylation
Fibrillarin	snoRNP component	Oxidative fragmentation	Scleroderma	[71*]
Histone H2A	DNA core	Ubiquitin conjugation/deconjugation	SLE	[19,62,63]
Histone H2B	DNA core	Transglutamination	SLE	[19,58]
La	Pol III transcription	Dephosphorylation	SLE	[54]
PARP	DNA binding protein, DNA repair	ADP-ribosylation	SLE	[57]
		Necrotic fragmentation		[76]
pp90	?U2-snRNP protein	Phosphorylation	SLE	[42]
pp34	SR splicing factor	Phosphorylation	SLE	[41,42]
pp46	?	Phosphorylation	SLE	[41]
pp17	?	Phosphorylation	SLE	[41]
Ribosomal RNA	Translational apparatus	RNA cleavage	SLE	[31,32,115]
SRp40	SR splicing factor	Phosphorylation	SLE	[42]
SRp55	SR splicing factor	Phosphorylation	SLE	[42]
SRp20	SR splicing factor	Phosphorylation	SLE	[42]
Topoisomerase I	DNA unwinding, SR protein kinase	Necrotic fragmentation	Scleroderma	[76]
		Oxidative fragmentation		[71*]
Topoisomerase II	DNA unwinding	Ubiquitin conjugation/deconjugation	SLE, Fibrosing Alveolitis	[40,64,116]
Troponin	Muscle function	Transglutamination	Necrobiosis Lipoidica	[58,117]
Tubulin	Cytoskeleton	Transglutamination	SLE	[58,118]
U1-70 kD	mRNA splicing	Necrotic fragmentation	SLE, MCTD	[76]
U1-snRNA	mRNA splicing	RNA cleavage	SLE, MCTD	[36]
UBF/NOR-90	Nucleolar transcription factor	Oxidative fragmentation	Sjögren's Syndrome,	[71*]
		Necrotic fragmentation	Scleroderma	[76]
Vimentin	Cytoskeleton	Citrullination	SLE, BD, RA,	[67]
			Sjögren's Syndrome
Y RNA	Unknown, associates with Ro	RNA cleavage	SLE	[35]

The acronyms used in this table (and not included in the abbreviations list at the start of the review) are listed in the appendix.

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