High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis

Table 2 Selected RNA profiling data

Accession number	Gene	Signal OA chip	Detection OA chip	Signal RA chip	Detection RA chip	Signal log ratio	Fold change	Change	P (for change)
U11870	CXCR1	119.6	A	163.5	A	0.5	NA	NC	0.5
U11872	CXCR1splice variant	180.7	A	232.5	A	-0.0	NA	NC	0.5
L19593	CXCR2	34.9	P	41.3	A	-0.2	NA	NC	0.5
X95876	CXCR3	478.6	A	1295.6	P	1.2	2.3	I	0.000051
X72755	CXCL9 (Mig)	177.5	P	1988.1	P	3.3	9.8	I	<0.000001
X02530	CXCL10 (IP-10)	189.3	P	656.6	P	2.2	4.6	I	<0.000001
J04132	TCR-ζ (CD247)	146.3	P	345	P	1.5	2.8	I	0.000133

RNA pools from patients suffering from rheumatoid arthritis (RA) or osteoarthritis (OA) were analyzed using Affymetrix HuGeneFL microarrays. Data assessment was done using Affymetrix Microarray Suite 5.0. CXCL, Cys–X–Cys ligand; CXCR, Cys–X–Cys receptor; NA, not applicable; TCR, T-cell receptor.

ISSN: 1478-6362