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Table 1 Structural and sequence comparisons of V-region heavy-chain (VH) and light-chain (VL) amino acids in several human monoclonal IgM anti-PR3 autoantibodies

From: What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)

Designation [Reference]

VH CDR3 sequence

VL CDR3 sequence

WGH1 [1*]

SQMSYYD FWSGYYRD QYY

SSYTSSSTE V

WG1 [6*]

VAVAGGFD PWGQGTLVT

 

WG2 [6*]

GE ID FWSGYFRE GLVGP

(ED FATYYC)LQHNSYP

  

   ←   JK3   →

WG3 [6*]

RGIFE GSGYYALDD WGQG

QQYYGTPFTFGPGTKVD IKR

  

   ←   JK3   →

WG4 [6*]

SRGTSCYMSCD CWGPRTL

QQHYGTPFTFGTKVD IKR

  1. Sequence in parentheses is PR3. Amino acids shown in bold type are very negatively charged.