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Table 1 Structural and sequence comparisons of V-region heavy-chain (VH) and light-chain (VL) amino acids in several human monoclonal IgM anti-PR3 autoantibodies

From: What you should know about PR3-ANCA: Structural aspects of antibodies to proteinase 3 (PR3)

Designation [Reference] VH CDR3 sequence VL CDR3 sequence
WGH1 [1*] SQMSYYD FWSGYYRD QYY SSYTSSSTE V
WG1 [6*] VAVAGGFD PWGQGTLVT  
WG2 [6*] GE ID FWSGYFRE GLVGP (ED FATYYC)LQHNSYP
      ←   JK3   →
WG3 [6*] RGIFE GSGYYALDD WGQG QQYYGTPFTFGPGTKVD IKR
      ←   JK3   →
WG4 [6*] SRGTSCYMSCD CWGPRTL QQHYGTPFTFGTKVD IKR
  1. Sequence in parentheses is PR3. Amino acids shown in bold type are very negatively charged.