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Table 3 Discontinuation rates at 1 year for anti-TNF agents in randomized clinical trials

From: Effective use of TNF antagonists

Trial No. of patients Patient characteristics Regimens Discontinuation rates (%)
ATTRACT [12] 428 Active RA despite methotrexate therapy; mean duration 9–12 years Infliximaba 21
    3 mg q 4 weeks  
    3 mg q 8 weeks  
    10 mg q 4 weeks  
    10 mg q 8 weeks  
    Placeboa (weekly) 50
ERA [14] 632 Early RA; mean duration <1 year (i.e. 11–12 months) Etanercept  
    25 mg twice weekly 15
    Methotrexate (mean, 19 mg) weekly 21
  1. aAll groups also received methotrexate, mean 16–17 mg/week. ATTRACT, Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis With Concomitant Therapy; ERA, Early Rheumatoid Arthritis.