Effective use of TNF antagonists

Table 3 Discontinuation rates at 1 year for anti-TNF agents in randomized clinical trials

Trial	No. of patients	Patient characteristics	Regimens	Discontinuation rates (%)
ATTRACT [12]	428	Active RA despite methotrexate therapy; mean duration 9–12 years	Infliximab^a	21
			3 mg q 4 weeks
			3 mg q 8 weeks
			10 mg q 4 weeks
			10 mg q 8 weeks
			Placebo^a (weekly)	50
ERA [14]	632	Early RA; mean duration <1 year (i.e. 11–12 months)	Etanercept
			25 mg twice weekly	15
			Methotrexate (mean, 19 mg) weekly	21

^aAll groups also received methotrexate, mean 16–17 mg/week. ATTRACT, Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis With Concomitant Therapy; ERA, Early Rheumatoid Arthritis.

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