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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts

Figure 1

The levels of LA, LIAS and oxidative stress in NL and SSc fibroblasts and plasma. A) Immunostaining of LA in NL and SSc dermal fibroblasts (n = 3 subjects). B) The expression of LIAS in dermal fibroblasts was examined by Western blotting (6 NL and 5 SSc subjects). C) Plasma LIAS levels in healthy subjects or SSc patients. D) LIAS levels in culture media from monocytes isolated from healthy subjects or SSc patients. E) Cellular O2 levels were detected by DHE. These representative images were from 5 NL and 5 SSc subjects. F) The effect of DHLA or NAC on peroxynitrite levels was measured (n = 4 subjects, p < 0.05). Results are expressed as mean ± S.E. and p < 0.05 was considered significant.

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