Table 2 Association of genetic markers with serological subgroups of rheumatoid arthritis: meta-analysis summary
Anti-CPP | Â | Â | Â | Â | Â |
| Â | Â | HLA-DRB1*04 -positive group | HLA-DRB1*04 -negative group | ||
Reference sequence for single nucleotide polymorphism (SNP) | Gene | Uncorrected P -value | Corrected P -value | Uncorrected P -value | Corrected P -value |
rs3890745 | MMEL1 | 0.1222 | 1.000 | 0.2888 | 1.000 |
rs2240340 | PADI4 | 0.3381 | 1.000 | 0.0004 | 0.038 |
rs2476601 | PTPN22 | 0.0142 | 1.000 | 0.2356 | 1.000 |
rs2523451 | MICA | 0.2676 | 1.000 | 0.8643 | 1.000 |
rs6457617 | HLA-DQ | 0.3272 | 1.000 | 0.0024 | 0.228 |
rs2064476 | HLA.DPB2 | 0.9817 | 1.000 | 0.0604 | 1.000 |
rs6920220 | TNFAIP3 | 0.5221 | 1.000 | 0.5579 | 1.000 |
rs42041 | CDK6 | 0.5768 | 1.000 | 0.0004 | 0.034 |
rs3761847 | TRAF1 | 0.3759 | 1.000 | 0.5073 | 1.000 |
rs4750316 | PRKCQ | 0.0225 | 1.000 | 0.9611 | 1.000 |
rs1328674 | HTR2A | 0.1093 | 1.000 | 0.2167 | 1.000 |
rs6416647 | CIITA | 0.4205 | 1.000 | 0.8600 | 1.000 |
anti-cit-Vimentin | Â | Â | Â | Â | Â |
| Â | Â | HLA-DRB1*04 -positive group | HLA-DRB1*04 -negative group | ||
Reference sequence for SNP | Gene | Uncorrected P -value | Corrected P -value | Uncorrected P -value | Corrected P -value |
rs3890745 | MMEL1 | 0.1174 | 1.000 | 0.8047 | 1.000 |
rs2240340 | PADI4 | 0.1918 | 1.000 | 0.2833 | 1.000 |
rs2476601 | PTPN22 | 0.0111 | 1.000 | 0.9087 | 1.000 |
rs2523451 | MICA | 0.0394 | 1.000 | 0.0713 | 1.000 |
rs6457617 | HLA-DQ | 0.6668 | 1.000 | 0.0727 | 1.000 |
rs2064476 | HLA.DPB2 | 0.0172 | 1.000 | 0.1853 | 1.000 |
rs6920220 | TNFAIP3 | 0.0601 | 1.000 | 0.9923 | 1.000 |
rs42041 | CDK6 | 0.8207 | 1.000 | 0.0009 | 0.088 |
rs3761847 | TRAF1 | 0.0877 | 1.000 | 0.2822 | 1.000 |
rs4750316 | PRKCQ | 0.8846 | 1.000 | 0.0231 | 1.000 |
rs1328674 | HTR2A | 0.0557 | 1.000 | 0.3165 | 1.000 |
rs6416647 | CIITA | 0.1542 | 1.000 | 0.3807 | 1.000 |
anti-CEP-1 | Â | Â | Â | Â | Â |
| Â | Â | HLA-DRB1*04 -positive group | HLA-DRB1*04 -negative group | ||
Reference sequence for SNP | Gene | Uncorrected P -value | Corrected P -value | Uncorrected P -value | Corrected P -value |
rs3890745 | MMEL1 | 0.9475 | 1.000 | 0.0240 | 1.000 |
rs2240340 | PADI4 | 0.6073 | 1.000 | 0.4651 | 1.000 |
rs2476601 | PTPN22 | 0.0001 | 0.006 | 0.4364 | 1.000 |
rs2523451 | MICA | 0.1623 | 1.000 | 0.1834 | 1.000 |
rs6457617 | HLA-DQ | 0.0558 | 1.000 | 0.0028 | 0.267 |
rs2064476 | HLA.DPB2 | 0.3083 | 1.000 | 0.6594 | 1.000 |
rs6920220 | TNFAIP3 | 0.8999 | 1.000 | 0.5037 | 1.000 |
rs42041 | CDK6 | 0.3235 | 1.000 | 0.0459 | 1.000 |
rs3761847 | TRAF1 | 0.6790 | 1.000 | 0.2747 | 1.000 |
rs4750316 | PRKCQ | 0.5904 | 1.000 | 0.0007 | 0.070 |
rs1328674 | HTR2A | 0.0582 | 1.000 | 0.2357 | 1.000 |
rs6416647 | CIITA | 0.0089 | 0.852 | 0.8989 | 1.000 |
anti- CitC1 III | Â | Â | Â | Â | Â |
| Â | Â | HLA-DRB1*04 -positive group | HLA-DRB1*04 -negative group | ||
Reference sequence for SNP | Gene | Uncorrected P -value | Corrected P -value | Uncorrected P -value | Corrected P -value |
rs3890745 | MMEL1 | 0.1310 | 1.000 | 0.2013 | 1.000 |
rs2240340 | PADI4 | 0.5328 | 1.000 | 0.1821 | 1.000 |
rs2476601 | PTPN22 | 0.2301 | 1.000 | 0.3068 | 1.000 |
rs2523451 | MICA | 0.3840 | 1.000 | 0.9666 | 1.000 |
rs6457617 | HLA-DQ | 0.4136 | 1.000 | 0.0021 | 0.201 |
rs2064476 | HLA.DPB2 | 0.9029 | 1.000 | 0.9872 | 1.000 |
rs6920220 | TNFAIP3 | 0.0148 | 1.000 | 0.6307 | 1.000 |
rs42041 | CDK6 | 0.4844 | 1.000 | 0.0054 | 0.522 |
rs3761847 | TRAF1 | 0.8086 | 1.000 | 0.3773 | 1.000 |
rs4750316 | PRKCQ | 0.5519 | 1.000 | 0.3662 | 1.000 |
rs1328674 | HTR2A | 0.6374 | 1.000 | 0.3458 | 1.000 |
rs6416647 | CIITA | 0.2613 | 1.000 | 0.7296 | 1.000 |