Figure 4

IL-10 modulates specific inflammasome component expression during antigen-induced arthritis (AIA). (A) Expression of inflammasome components; Nlrp3, Aim2, Casp1, Casp12, Nlrp1, Asc, Rigi, Nod1 and Nod2 were examined in synovial mRNA of WT (closed circles) and IL-10KO (open circles) mice three days after AIA induction. Values are relative to 18S ribosomal RNA (n = 5-9, ^*P <0.05). (B) Changes in Nlrp3, Aim2, Casp1 and Casp12 in WT joint sections treated without/with intra-articular-administrated anti-IL-10R or isotype control antibody at the onset of AIA. Values are presented for individual joints taken at day 3 post AIA and are relative to 18S ribosomal RNA (n = 3-15, ^*P <0.05). IL-10KO, interleukin-10-deficient; WT, wild-type.