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Table 3 Association testing results for MHC alleles DRB1*11:04 and DRB1*07:01

From: An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3

  Results forDRB1*11:04 Results forDRB1*07:01
Group Mean allele dosage OR (95% CI) Pvalue Mean allele dosage OR (95% CI) Pvalue
Controls (n =4458) 0.037 1 (ref)   0.287 1 (ref)  
Cases (n =486) 0.105 3.07 (2.00 − 4.71) 2.8 × 10−7 0.167 0.58 (0.46 − 0.74) 1.4 × 10−5
ACA-positive (44% of cases) 0.080 2.46 (1.28 − 4.73)   0.105 0.34 (0.22 − 0.53)  
ACA-negative (56% of cases) 0.118 3.62 (2.13–6.16) 0.19* 0.213 0.79 (0.59 – 1.07) 0.002*
Scl70-positive (16% of cases) 0.174 8.22 (3.74 – 18.1)   0.294 1.28 (0.79 – 2.06)  
Scl70-negative (84% of cases) 0.088 2.47 (1.52 – 4.02) 0.021* 0.145 0.49 (0.37 – 0.65) 0.0012*
ACA & Scl70-negative (40% of cases) 0.095 2.61 (1.36 – 5.00)   0.144 0.66 (0.46 – 0.96)  
  1. *These P values are tests of heterogeneity, comparing allele dosages in cases positive and negative for the two antibodies. Mean dosage = mean expected number of copies of alleles carried by individuals in group. OR (odds ratio) = increase in odds of being a case for each 1-unit increase in allele dosage. MHC, major histocompatibility complex; CI, confidence interval; ACA, anti-centromere antibody.