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Table 3 Association testing results for MHC alleles DRB1*11:04 and DRB1*07:01

From: An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3

 

Results forDRB1*11:04

Results forDRB1*07:01

Group

Mean allele dosage

OR (95% CI)

Pvalue

Mean allele dosage

OR (95% CI)

Pvalue

Controls (n =4458)

0.037

1 (ref)

 

0.287

1 (ref)

 

Cases (n =486)

0.105

3.07 (2.00 − 4.71)

2.8 × 10−7

0.167

0.58 (0.46 − 0.74)

1.4 × 10−5

ACA-positive (44% of cases)

0.080

2.46 (1.28 − 4.73)

 

0.105

0.34 (0.22 − 0.53)

 

ACA-negative (56% of cases)

0.118

3.62 (2.13–6.16)

0.19*

0.213

0.79 (0.59 – 1.07)

0.002*

Scl70-positive (16% of cases)

0.174

8.22 (3.74 – 18.1)

 

0.294

1.28 (0.79 – 2.06)

 

Scl70-negative (84% of cases)

0.088

2.47 (1.52 – 4.02)

0.021*

0.145

0.49 (0.37 – 0.65)

0.0012*

ACA & Scl70-negative (40% of cases)

0.095

2.61 (1.36 – 5.00)

 

0.144

0.66 (0.46 – 0.96)

 
  1. *These P values are tests of heterogeneity, comparing allele dosages in cases positive and negative for the two antibodies. Mean dosage = mean expected number of copies of alleles carried by individuals in group. OR (odds ratio) = increase in odds of being a case for each 1-unit increase in allele dosage. MHC, major histocompatibility complex; CI, confidence interval; ACA, anti-centromere antibody.
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Arthritis Research & Therapy

ISSN: 1478-6362

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