Figure 8

Regulatory activity of CD4⁺CD25^low/-GITR⁺and CD4⁺CD25^highGITR^-cells from HC differs from that of SLE patients . Inhibition of proliferation by CD4⁺CD25^low/-GITR⁺ cells and CD4⁺CD25^highGITR^- cells observed in autologous (see Figure 5) and heterologous (see Figure 7) co-cultures is shown (A-D). **P <0.01 and ***P <0.001 according to Mann-Whitney U test comparing inhibition by CD4⁺CD25^low/-GITR⁺ cells and CD4⁺CD25^highGITR^- cells. (E) Differences between regulatory activity exerted by CD4⁺CD25^highGITR^- and CD4⁺CD25^low/-GITR⁺ Treg from each HC (circle) and SLE patient (triangle) is reported, as shown in right plots of Figures 5 and 7. Horizontal lines indicate mean differences. ***P <0.001, according to the Mann-Whitney U test comparing differences in HC and SLE.