Skip to main content

Advertisement

Table 1 Clinical characteristics and autoantibody profiles of patients at time of muscle biopsy a and results of immunohistochemical analysis of biopsies

From: Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies

Patient Dg Years since Dg Anti-Jo-1 Anti-Ro52 Anti-Ro60 Other autoantibodies Treatment duration (yr) Treatment at time of biopsy Cumulative clinical manifestations Infiltrate score** BAFF-R BCMA TACIb CD19 CD138 TACI/vesselb
1 Def PM −0.8 + 0 No ILD, A, R 3 + + + + +
2 Def PM 0 + RNP-70 0 No ILD 0 - + +
3 Def PM 0.4 + Ku-72 0.3 Yes ILD, A, R, MH, SS 0 NA NA NA
4 Def PM 1.6 + 1.6 Yes ILD, E, T 2 + +
5 Prob PM 2.9 + 2.8 Yes ILD 3 + + + + +
6 Prob DM 22.5 + + + La, Ku-86 28.5 Yes ILD, R, SR 2 +
7 Prob PM 6.5 + + La 6.4 Yes A, pSS 3 + + + + + +
8 Def IBM 0.5 + + La 0.4 Yes pSS 3 + + + + +
9 Def PM 0.2 + 0.2 Yes ILD, R 2 NA NA +
10 Def IBM* 0 + 13.7 Yes R 2 + NA NA +
11 Def DM 8.8 Mi-2, PM-Scl 9.0 Yes SR, SS 2 + +
12 Def PM 0.8 0.5 Yes   0
13 Prob PM −0.1 0 No   2 + +
14 Prob DM 0 0 No SR 0 +
15 Def PM 5.0 4.9 Yes   2 + +
16 Def IBM 0.8 Histones 0.8 Yes E 2 + + +
17 Def IBM* 0 9.0 Yes R 1 + + +
18 Def DM 0.3 0.3 Yes SR 1 NA NA +
19 Prob DM 0.1 0.2 Yes SR 2 + NA NA +
20 Def IBM 8.4 8.4 Yes   0 NA NA +
21 Def PM 9.4 9.7 Yes A 0 NA NA +
22 Def DM 13.2 Ku-86 13.2 Yes SR 1
23 Prob IBM* −1.1 2.1 Yes   0 + NA NA +
  1. aA, Arthritis; BAFF-R, B-cell-activating factor of the tumour necrosis factor family receptor; BCMA, B-cell maturation antigen; Def, Definitive; Dg, Diagnosis; DM, Dermatomyositis; E, oesophagus; IBM, Inclusion body myositis; ILD, Interstitial lung disease; MH, Mechanic’s hands; NA, Not assessed; PM, Polymyositis; Prob, Probable; pSS, Primary Sjögren’s syndrome; R, Raynaud’s phenomenon; SR, Skin rash; SS, Sjögren’s syndrome; T, Thrombosis; TACI, Transmembrane activator and calcium modulator and cyclophilin ligand interactor. bTACI was also expressed in vessels (*) at time of biopsy diagnosed as PM, (**) score: 0=no infiltrate; 1=scattered cells; 2=one or two small infiltrates; 3=several small or one big infiltrate or infiltrate + scattered cells.