Table 1 Clinical characteristics and autoantibody profiles of patients at time of muscle biopsy a and results of immunohistochemical analysis of biopsies
Patient | Dg | Years since Dg | Anti-Jo-1 | Anti-Ro52 | Anti-Ro60 | Other autoantibodies | Treatment duration (yr) | Treatment at time of biopsy | Cumulative clinical manifestations | Infiltrate score** | BAFF-R | BCMA | TACIb | CD19 | CD138 | TACI/vesselb |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Def PM | −0.8 | + | − | − | − | 0 | No | ILD, A, R | 3 | + | + | − | + | + | + |
2 | Def PM | 0 | + | − | − | RNP-70 | 0 | No | ILD | 0 | - | − | + | − | − | + |
3 | Def PM | 0.4 | + | − | − | Ku-72 | 0.3 | Yes | ILD, A, R, MH, SS | 0 | NA | − | − | NA | NA | − |
4 | Def PM | 1.6 | + | − | − | − | 1.6 | Yes | ILD, E, T | 2 | − | − | − | − | + | + |
5 | Prob PM | 2.9 | + | − | − | − | 2.8 | Yes | ILD | 3 | + | + | + | − | + | + |
6 | Prob DM | 22.5 | + | + | + | La, Ku-86 | 28.5 | Yes | ILD, R, SR | 2 | − | + | − | − | − | − |
7 | Prob PM | 6.5 | − | + | + | La | 6.4 | Yes | A, pSS | 3 | + | + | + | + | + | + |
8 | Def IBM | 0.5 | − | + | + | La | 0.4 | Yes | pSS | 3 | + | + | + | − | + | + |
9 | Def PM | 0.2 | − | + | − | − | 0.2 | Yes | ILD, R | 2 | − | − | − | NA | NA | + |
10 | Def IBM* | 0 | − | + | − | − | 13.7 | Yes | R | 2 | − | − | + | NA | NA | + |
11 | Def DM | 8.8 | − | − | − | Mi-2, PM-Scl | 9.0 | Yes | SR, SS | 2 | − | − | − | − | + | + |
12 | Def PM | 0.8 | − | − | − | − | 0.5 | Yes | 0 | − | − | − | − | − | − | |
13 | Prob PM | −0.1 | − | − | − | − | 0 | No | 2 | − | − | − | − | + | + | |
14 | Prob DM | 0 | − | − | − | − | 0 | No | SR | 0 | − | − | − | − | − | + |
15 | Def PM | 5.0 | − | − | − | − | 4.9 | Yes | 2 | − | − | + | − | + | − | |
16 | Def IBM | 0.8 | − | − | − | Histones | 0.8 | Yes | E | 2 | − | + | − | − | + | + |
17 | Def IBM* | 0 | − | − | − | − | 9.0 | Yes | R | 1 | + | − | − | − | + | + |
18 | Def DM | 0.3 | − | − | − | − | 0.3 | Yes | SR | 1 | − | − | − | NA | NA | + |
19 | Prob DM | 0.1 | − | − | − | − | 0.2 | Yes | SR | 2 | − | + | − | NA | NA | + |
20 | Def IBM | 8.4 | − | − | − | − | 8.4 | Yes | 0 | − | − | − | NA | NA | + | |
21 | Def PM | 9.4 | − | − | − | − | 9.7 | Yes | A | 0 | − | − | − | NA | NA | + |
22 | Def DM | 13.2 | − | − | − | Ku-86 | 13.2 | Yes | SR | 1 | − | − | − | − | − | − |
23 | Prob IBM* | −1.1 | − | − | − | − | 2.1 | Yes | 0 | − | − | + | NA | NA | + |