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Table 4 Nonclustering variables compared across clusters a

From: OMERACT-based fibromyalgia symptom subgroups: an exploratory cluster analysis

Variables

Cluster 1b(n = 150)

Cluster 2c(n = 171)

Cluster 3d(n = 136)

Cluster 4e(n = 124)

P-valuef

Age, yr

57.0 (14.5)

57.6 (11.3)

52.5 (12.4)

52.2 (9.7)

<0.0001

BMI, kg/m2

28.6 (7.6)

31.5 (7.8)

29.2 (6.9)

30.8 (7.8)

0.0030

FM research survey

     

WPI

11.1 (3.5)

12.8 (3.7)

12.5 (3.6)

14.3 (3.5)

<0.0001

SS

7.6 (1.8)

8.7 (1.8)

9.1 (1.8)

10.5 (1.4)

<0.0001

BPI Pain interference

3.4 (1.9)

5.9 (1.8)

5.9 (1.6)

7.9 (1.3)

<0.0001

MFI-20

     

General

15.0 (2.8)

17.8 (2.1)

17.5 (2.2)

19.0 (1.6)

<0.0001

Reduced activity

11.7 (3.9)

15.0 (3.4)

14.6 (3.4)

17.6 (2.3)

<0.0001

Reduced motivation

9.8 (3.1)

12.1 (3.5)

12.9 (3.3)

15.5 (2.9)

<0.0001

Mental

10.5 (3.8)

12.4 (3.8)

13.9 (3.9)

16.6 (2.9)

<0.0001

Total

59.3 (11.8)

74.5 (10.5)

74.4 (10.4)

87.1 (7.1)

<0.0001

SF-36

     

Physicalg

36.5 (8.3)

26.2 (7.3)

33.1 (6.8)

25.6 (6.4)

<0.0001

Mentalg

48.9 (9.3)

45.4 (10.1)

34.5 (9.3)

28.6 (10.3)

<0.0001

FIQ

     

Tenderness

5.8 (2.8)

7.8 (2.3)

7.7 (2.3)

8.8 (1.6)

<0.0001

Impact

5.7 (4.5)

11.5 (5.1)

11.7 (4.7)

16.3 (3.7)

<0.0001

Total

34.3 (11.7)

58.1 (13.0)

57.7 (10.8)

77.7 (8.6)

<0.0001

POMS

     

Anger-Hostility

3.0 (3.3)

3.2 (2.7)

6.8 (4.2)

8.6 (4.4)

<0.0001

Vigor-Activityg

6.5 (3.6)

3.9 (3.1)

3.8 (2.8)

2.4 (2.6)

<0.0001

Fatigue-Inertia

10.2 (3.7)

13.6 (3.6)

14.7 (3.1)

16.9 (2.6)

<0.0001

Confusion-Bewilderment

4.7 (2.9)

6.1 (2.7)

9.1 (2.8)

12.7 (3.2)

<0.0001

  1. aData are mean ± SD. BMI, Body mass index; BPI, Brief Pain Inventory; FIQ, Fibromyalgia Impact Questionnaire; FM, Fibromyalgia; MFI, Multidimensional Fatigue Inventory; POMS, Profile of Mood States; SF-36, 36-item Medical Outcomes Study Short Form health survey; SS, Symptom severity; WPI, Widespread pain index. bLow symptom intensity. cModerate symptoms, low negative mood. dModerate symptoms, higher negative mood and dyscognition. eHigh symptom severity. fP-values are from the omnibus analysis of variance test across the four clusters. Pairwise comparisons between clusters also showed significant differences in all cases, except for the following: cluster 1 versus cluster 2 with respect to age (P = 0.62), cluster 1 versus cluster 3 with respect to BMI (P = 0.51), cluster 2 versus cluster 4 with respect to both BMI (P = 0.49) and SF-36 Physical (P = 0.53) and cluster 3 versus cluster 4 with respect to both age (P = 0.86) and BMI (P = 0.08). Differences between clusters 2 and 3 were not significant for all variables, except age, BMI, MFI Reduced Motivation, MFI Mental Fatigue, SF-36 Physical, SF-36 Mental, POMS Fatigue-Inertia and POMS Confusion-Bewilderment. gLower scores are worse for these scales.