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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Down-regulating peroxisome proliferator-activated receptor-gamma coactivator-1beta alleviates the proinflammatory effect of rheumatoid arthritis fibroblast-like synoviocytes through inhibiting extracellular signal-regulated kinase, p38 and nuclear factor-kappaB activation

Figure 6

Peroxisome proliferator-activated receptor-gamma coactivator-1 β (PGC-1β) promotes NF-κB transcription in rheumatoid arthritis (RA)-fibrolast-like synoviocytes (FLS). (A). After PGC-1β overexpression, the mRNA expression of ERK, p38 and NF-κB in FLS was evaluated by qPCR. (B) After RA-FLS transfected with a wild type-NF-κB reporter region (WT) and plasmid pcDNA3.1-PGC-1β or pcDNA3.1, the luciferase activities were measured on a spectraMax M5 reader. (C) After RA-FLS transfected with plasmid pcDNA3.1-PGC-1β and WT region or a mutated-NF-κB reporter construct (MUT), the luciferase activities were measured on a spectraMax M5 reader. The data are represented by mean ± SD from three independent experiments. **P <0.01, ***P <0.001.

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Arthritis Research & Therapy

ISSN: 1478-6362

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