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Table 3 CRP haplotype build, frequency and effect on serum C-reactive protein and Disease Activity Score in 28 joints at baseline and year 1 a

From: CRP genotype and haplotype associations with serum C-reactive protein level and DAS28 in untreated early rheumatoid arthritis patients

Haplotype Frequency Baseline CRP, effect (CI) Year 1 CRP, effect (CI) Baseline DAS28, effect (CI) Year 1 DAS28, effect (CI)
H1 (CACT) 30.5% 96% (73 to 126) 99% (77 to 126) 102% (98 to 107) 105% (97 to 113)
H2 (TGCT) 25.7% 74% (55 to 99) 91% (70 to 118) 99% (94 to 103) 97% (89 to 106)
H3 (CGCG) 31.4% 100% 100% 100% 100%
H4 (CGCT) 6.2% 66% (41 to 107) 121% (80 to 184) 95% (88 to 103) 102% (89 to 116)
H5 (TGGT) 5.5% 64% (40 to 103) 86% (56 to 134) 101% (93 to 108) 110% (95 to 124)
  1. Haplotype defining SNPs = (rs1205, rs1130864, rs1800947, rs2808632). The effects of each haplotype were given relative to the most frequent haplotype, which was used as reference. CRP, C-reactive protein; DAS28, Disease Activity Score in 28 joints; SNP, Single-nucleotide polymorphism.