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Figure 6 | Arthritis Research & Therapy

Figure 6

From: Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

Figure 6

Reduced expression of toll-like receptor 9 (TLR9) by B cells from active systemic lupus erythematosus (SLE) patients. Representative flow cytometry histogram showing TLR9 staining for B cells (left). Combined data for TLR9 detection of B cells obtained from 6 SLE patients and 4 healthy donors (HD), respectively, did not show a significant difference in TLR9 detection, but B cells from patients with more active SLE (SLE disease activity index (SLEDAI) ≥6) were found to express reduced TLR9 (Mann-Whitney U-test; ns: not significant; *P <0.05) (right panel). Hhistogram: red line TLR9, gray line isotype- phycoerythrin (PE) and black line control antibody; MFI: mean fluorescence intensity of TLR9.

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