Potential role of the lectin pathway of complement in the pathogenesis and disease manifestations of systemic sclerosis: a case-control and cohort study

Table 4 Association of MBL and ficolin-2 with SSc disease manifestations

Variables	MBL levels (μg/ml), median (IQR)	*MBL2*low-producing genotype, n (%)	Ficolin-2 levels (μg/ml), mean (SD)
Skin manifestations
Calcinosis (yes vs. no)	2.1 (0.7-3.2) vs. 0.8 (0.1-2.1)	2 (7) vs. 16 (27)	0.6 (0.3) vs. 0.6 (0.3)
P value	0.005	0.02	0.9
Pitting (yes vs. no)	1.8 (0.5-3.0) vs. 0.8 (0.1-1.9)	6 (13) vs. 12 (29)	0.6 (0.4) vs. 0.5 (0.3)
P value	0.007	0.06	0.2
Digital ulcers (yes vs. no)	2.7 (1.0-4.1) vs. 1.0 (0.2-2.3)	1 (8) vs. 17 (22)	0.6 (0.4) vs. 0.6 (0.3)
P value	0.01	0.2	0.5
Organ involvement
PAH (yes vs. no)	1.7 (0.3-3.8) vs. 1.1 (0.3-2.6)	1 (13) vs. 17 (21)	0.5 (0.2) vs. 0.6 (0.4)
P value	0.5	1	0.6
ILD (yes vs. no)	1.7 (0.5-2.9) vs. 0.9 (0.2-2.1)	6 (15) vs. 12 (25)	0.7 (0.3) vs. 0.5 (0.3)
P value	0.11	0.3	0.04
Renal crisis (yes vs. no)	1.7 (0.2-4.1) vs. 1.1 (0.3-2.6)	1 (25) vs. 17 (20)	1.0 (0.3) vs. 0.6 (0.3)
P value	0.6	1	0.01
Bowel dysmotility (yes vs. no)	3.1 (0.8-4.2) vs. 1.1 (0.3-2.4)	1 (11) vs. 17 (21)	0.6 (0.3) vs. 0.4 (0.2)
P value	0.14	0.7	0.04

ILD, interstitial lung disease; IQR, interquartile range; MBL, mannose-binding lectin; PAH, pulmonary arterial hypertension; SD, standard deviation; SSc, systemic sclerosis.

ISSN: 1478-6362