Figure 6

Proposed schematic model showing how rapamycin modulates osteoarthritis (OA) in our animal model. There are three potential mechanisms by which rapamycin has a beneficial effect on OA (autophagy, vascular endothelial growth factor (VEGF), and the Akt pathway). mTOR, mammalian target of rapamycin; MMP13, matrix metallopeptidase 13; COL10A1, collagen, type X alpha 1.